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@ARTICLE{Whitehouse:177752,
      author       = {J. P. Whitehouse and M. Howlett and A. Federico$^*$ and M.
                      Kool$^*$ and R. Endersby and N. G. Gottardo},
      title        = {{D}efining the molecular features of radiation-induced
                      glioma: {A} systematic review and meta-analysis.},
      journal      = {Neuro-oncology advances},
      volume       = {3},
      number       = {1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-02793},
      pages        = {vdab109},
      year         = {2021},
      abstract     = {Cranial radiation therapy is essential in treating many
                      pediatric cancers, especially brain tumors; however, its use
                      comes with the risk of developing second malignancies.
                      Cranial radiation-induced gliomas (RIGs) are aggressive
                      high-grade tumors with a dismal prognosis, for which no
                      standard therapy exists. A definitive molecular signature
                      for RIGs has not yet been established. We sought to address
                      this gap by performing a systematic review and meta-analysis
                      of the molecular features of cranial RIGs.A systematic
                      review of the literature was performed according to
                      Preferred Reporting Items for Systematic Reviews and
                      Meta-Analyses guidelines. Articles and case reports that
                      described molecular analyses of cranial radiation-induced
                      high-grade gliomas were identified and evaluated, and data
                      extracted for collation.Of 1727 records identified, 31 were
                      eligible, containing 102 unique RIGs with molecular data.
                      The most frequent genetic alterations in RIGs included
                      PDGFRA or TP53 mutations, PDGFRA or CDK4 amplifications, and
                      CDKN2A deletion, along with 1q gain, 1p loss and 13q loss.
                      Of note, mutations in ACVR1, EGFR, H3F3A, HIST1H3B,
                      HIST1H3C, IDH2, SMARCB1 or the TERT promoter were not
                      observed. A comparative analysis revealed that RIGs are
                      molecularly distinct from most other astrocytomas and
                      gliomas and instead align most closely with the
                      $pedGBM_RTK1$ subgroup of pediatric glioblastoma.This
                      comprehensive analysis highlights the major molecular
                      features of RIGs, demonstrates their molecular distinction
                      from many other astrocytomas and gliomas, and reveals
                      potential genetic drivers and therapeutic targets for this
                      currently fatal disease.},
      subtyp        = {Review Article},
      keywords     = {Radiation-induced glioma (Other) / cancer (Other) /
                      molecular (Other) / pediatric (Other) / radiation (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34859225},
      pmc          = {pmc:PMC8633655},
      doi          = {10.1093/noajnl/vdab109},
      url          = {https://inrepo02.dkfz.de/record/177752},
}