%0 Journal Article
%A Chandrapalan, Subashini
%A Bosch, Sofie
%A Cubiella, Joaquín
%A Guardiola, Jordi
%A Kimani, Peter
%A Mulder, Chris
%A Persaud, Krishna
%A de Meij, Tim G J
%A Altomare, Donato F
%A Brenner, Herman
%A de Boer, Nanne K H
%A Ricciardiello, Luigi
%A Arasaradnam, Ramesh P
%T Systematic review with meta-analysis: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer.
%J Alimentary pharmacology & therapeutics
%V 54
%N 1
%@ 0269-2813
%C Oxford
%I Wiley-Blackwell
%M DKFZ-2021-02931
%P 14-23
%D 2021
%X Faecal immunochemical test (FIT) is emerging as a valid test to rule-out the presence of colorectal cancer (CRC). However, the accuracy of FIT is dependent on the cut-off applied. An additional low-cost test could improve further detection of CRC.To evaluate the efficacy of combined FIT and volatile organic compounds (VOC) in the detection of CRC within symptomatic populations.Systematic reviews on the diagnostic accuracy of FIT and VOC, for the detection of CRC, were updated. Meta-analyses were performed adopting a bivariate model for sensitivity and specificity. Clinical utility of combined FIT and VOC was estimated using Fagan's nomogram. Post-test probability of FIT negatives was used as a pre-test probability for VOC.The pooled sensitivity and specificity of FIT at 10 µg/g faeces, for the detection of CRC, were 0.914 (95
%K Colorectal Neoplasms: diagnosis
%K Colorectal Neoplasms: epidemiology
%K Early Detection of Cancer
%K Feces
%K Humans
%K Occult Blood
%K Sensitivity and Specificity
%K Volatile Organic Compounds
%K Volatile Organic Compounds (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34004036
%R 10.1111/apt.16405
%U https://inrepo02.dkfz.de/record/177909