TY  - JOUR
AU  - Chandrapalan, Subashini
AU  - Bosch, Sofie
AU  - Cubiella, Joaquín
AU  - Guardiola, Jordi
AU  - Kimani, Peter
AU  - Mulder, Chris
AU  - Persaud, Krishna
AU  - de Meij, Tim G J
AU  - Altomare, Donato F
AU  - Brenner, Herman
AU  - de Boer, Nanne K H
AU  - Ricciardiello, Luigi
AU  - Arasaradnam, Ramesh P
TI  - Systematic review with meta-analysis: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer.
JO  - Alimentary pharmacology & therapeutics
VL  - 54
IS  - 1
SN  - 0269-2813
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DKFZ-2021-02931
SP  - 14-23
PY  - 2021
AB  - Faecal immunochemical test (FIT) is emerging as a valid test to rule-out the presence of colorectal cancer (CRC). However, the accuracy of FIT is dependent on the cut-off applied. An additional low-cost test could improve further detection of CRC.To evaluate the efficacy of combined FIT and volatile organic compounds (VOC) in the detection of CRC within symptomatic populations.Systematic reviews on the diagnostic accuracy of FIT and VOC, for the detection of CRC, were updated. Meta-analyses were performed adopting a bivariate model for sensitivity and specificity. Clinical utility of combined FIT and VOC was estimated using Fagan's nomogram. Post-test probability of FIT negatives was used as a pre-test probability for VOC.The pooled sensitivity and specificity of FIT at 10 µg/g faeces, for the detection of CRC, were 0.914 (95
KW  - Colorectal Neoplasms: diagnosis
KW  - Colorectal Neoplasms: epidemiology
KW  - Early Detection of Cancer
KW  - Feces
KW  - Humans
KW  - Occult Blood
KW  - Sensitivity and Specificity
KW  - Volatile Organic Compounds
KW  - Volatile Organic Compounds (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34004036
DO  - DOI:10.1111/apt.16405
UR  - https://inrepo02.dkfz.de/record/177909
ER  -