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@ARTICLE{SchererTrame:177926,
      author       = {S. Scherer-Trame$^*$ and L. Jansen$^*$ and L.
                      Koch-Gallenkamp$^*$ and V. Arndt$^*$ and J. Chang-Claude$^*$
                      and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{Q}uality of life, distress, and posttraumatic growth
                      5 years after colorectal cancer diagnosis according to
                      history of inpatient rehabilitation.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {148},
      number       = {11},
      issn         = {0171-5216},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2021-02948},
      pages        = {3015-3028},
      year         = {2022},
      note         = {#EA:C120#LA:C070#LA:C120# / 2022 Nov;148(11):3015-3028},
      abstract     = {In Germany, almost every other colorectal cancer (CRC)
                      patient undergoes inpatient cancer rehabilitation (ICR), but
                      research on long-term outcomes is sparse. We aimed to assess
                      health-related quality of life (HRQOL), distress, and
                      posttraumatic growth among former rehabilitants and
                      non-rehabilitants as well as respective differences and to
                      estimate disease-related quality of life deficits in both
                      groups.HRQOL (EORTC-QLQ-C30/CR29), distress (QSC-R10), and
                      posttraumatic growth (PTGI) were assessed according to past
                      ICR in patients 5-year post-CRC-diagnosis in the German
                      DACHS study. Least square mean differences in HRQOL scores
                      and elevated distress levels (QSC-R10 > 14 points) by ICR
                      were estimated by confounder-adjusted linear and logistic
                      regression, respectively. Differences in PTGI scales were
                      tested for statistical significance. EORTC-QLQ-C30 reference
                      scores from population controls were accessed from the LinDE
                      study to estimate disease-related deficits in both treatment
                      $groups.49\%$ of the included 1906 CRC survivors had
                      undergone ICR. Rehabilitants reported lower HRQOL scores
                      than non-rehabilitants in several dimensions of the
                      EORTC-QLQ-C30/CR29. Differences were pronounced among
                      younger survivors (< 70 years). In younger survivors, past
                      ICR also predicted elevated distress. However, rehabilitants
                      showed higher posttraumatic growth. When compared to 934
                      population controls, non-rehabilitants and older
                      rehabilitants reported HRQOL scores (EORTC-QLQ-C30) similar
                      to controls except higher levels of bowel dysfunctions,
                      whereas younger rehabilitants experienced deficits regarding
                      most scales (13/15).Our findings suggest a high disease
                      burden 5 years after diagnosis in particular among younger
                      CRC survivors who had undergone ICR. Observed HRQOL deficits
                      are possibly linked to the initial indication for ICR and
                      rehabilitants may benefit from effective follow-up concepts
                      after ICR.},
      keywords     = {Cancer survivorship (Other) / Colorectal cancer (Other) /
                      Distress (Other) / Health-related quality of life (Other) /
                      Inpatient rehabilitation (Other) / Posttraumatic growth
                      (Other)},
      cin          = {C120 / C070 / M110 / C071 / C020 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)M110-20160331 / I:(DE-He78)C071-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34874489},
      doi          = {10.1007/s00432-021-03865-3},
      url          = {https://inrepo02.dkfz.de/record/177926},
}