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| Home > Publications database > Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity. > print |
| Home > Publications database > Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity. > print |
| 001 | 178063 | ||
| 005 | 20240229133758.0 | ||
| 024 | 7 | _ | |a 10.1016/j.immuni.2021.11.004 |2 doi |
| 024 | 7 | _ | |a pmid:34879221 |2 pmid |
| 024 | 7 | _ | |a 1074-7613 |2 ISSN |
| 024 | 7 | _ | |a 1097-4180 |2 ISSN |
| 024 | 7 | _ | |a altmetric:118323957 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2021-03072 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Hanna, Bola S |0 P:(DE-He78)1c2351213e0199e6bd4efaceac511917 |b 0 |e First author |
| 245 | _ | _ | |a Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity. |
| 260 | _ | _ | |a New York, NY |c 2021 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1642516325_15946 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:B060#LA:B060# / 2021 Dec 14;54(12):2825-2841.e10 |
| 520 | _ | _ | |a T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1hi, functionally impaired CD8+ T cells that accumulated in secondary lymphoid organs during disease progression and a functionally competent PD-1int subset. Frequencies of PD-1int TCF-1+ CD8+ T cells decreased upon Il10rb or Stat3 deletion, leading to accumulation of PD-1hi cells and accelerated tumor progression. Mechanistically, inhibition of IL-10R signaling altered chromatin accessibility and disrupted cooperativity between the transcription factors NFAT and AP-1, promoting a distinct NFAT-associated program. Low IL10 expression or loss of IL-10R-STAT3 signaling correlated with increased frequencies of exhausted CD8+ T cells and poor survival in CLL and in breast cancer patients. Thus, balance between PD-1hi, exhausted CD8+ T cells and functional PD-1int TCF-1+ CD8+ T cells is regulated by cell-intrinsic IL-10R signaling, with implications for immunotherapy. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de |
| 650 | _ | 7 | |a CD8(+) T cells |2 Other |
| 650 | _ | 7 | |a CLL |2 Other |
| 650 | _ | 7 | |a IL-10 |2 Other |
| 650 | _ | 7 | |a IL-10R |2 Other |
| 650 | _ | 7 | |a NFAT |2 Other |
| 650 | _ | 7 | |a PD-1 heterogeneity |2 Other |
| 650 | _ | 7 | |a STAT3 |2 Other |
| 650 | _ | 7 | |a T cell exhaustion |2 Other |
| 650 | _ | 7 | |a TCF-1 |2 Other |
| 650 | _ | 7 | |a tumor microenvironment |2 Other |
| 700 | 1 | _ | |a Llaó-Cid, Laura |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Iskar, Murat |0 P:(DE-He78)f28fcc92d5c00f3ee511e3319c699b38 |b 2 |
| 700 | 1 | _ | |a Roessner, Philipp M |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Klett, Lara C |0 P:(DE-He78)dd57fd8197d9c5e0290f104db294e019 |b 4 |
| 700 | 1 | _ | |a Wong, John K L |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Paul, Yashna |0 P:(DE-He78)1cd5686a9bcef9182c18a1cb799637d3 |b 6 |
| 700 | 1 | _ | |a Ioannou, Nikolaos |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Öztürk, Selcen |0 P:(DE-He78)c3e32dca3eea6c46d4d140757aaf6e18 |b 8 |
| 700 | 1 | _ | |a Mack, Norman |0 P:(DE-He78)e73a0a4fab40344d89d693cbe1df3109 |b 9 |
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| 700 | 1 | _ | |a Stilgenbauer, Stephan |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Dietrich, Sascha |0 P:(DE-He78)6333b389d0abc96ef7f2f6e049a8f8c4 |b 15 |
| 700 | 1 | _ | |a Schmidt, Manfred |0 P:(DE-He78)b91bec47a4148ba68a58ab292d5860f2 |b 16 |
| 700 | 1 | _ | |a Gabriel, Richard |0 P:(DE-He78)647431b5ca55b04fdf3c2fce31ef1915 |b 17 |
| 700 | 1 | _ | |a Rippe, Karsten |0 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |b 18 |
| 700 | 1 | _ | |a Feuerer, Markus |0 P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f |b 19 |
| 700 | 1 | _ | |a Ramsay, Alan G |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Lichter, Peter |0 P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c |b 21 |
| 700 | 1 | _ | |a Zapatka, Marc |0 P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7 |b 22 |
| 700 | 1 | _ | |a Seiffert, Martina |0 P:(DE-He78)e67f907703fcb2cf909f4d72d50268b5 |b 23 |e Last author |
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