%0 Journal Article
%A Müller, Max
%A Egger, Nico
%A Sommer, Stefan
%A Wilferth, Tobias
%A Meixner, Christian R
%A Laun, Frederik Bernd
%A Mennecke, Angelika
%A Schmidt, Manuel
%A Huhn, Konstantin
%A Rothhammer, Veit
%A Uder, Michael
%A Dörfler, Arnd
%A Nagel, Armin
%T Direct imaging of white matter ultrashort T2∗ components at 7 tesla.
%J Magnetic resonance imaging
%V 86
%@ 0730-725X
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2021-03166
%P 107 - 117
%D 2021
%Z #LA:E020#
%X To demonstrate direct imaging of the white matter ultrashort T2∗ components at 7 Tesla using inversion recovery (IR)-enhanced ultrashort echo time (UTE) MRI. To investigate its characteristics, potentials and limitations, and to establish a clinical protocol.The IR UTE technique suppresses long T2∗ signals within white matter by using adiabatic inversion in combination with dual-echo difference imaging. Artifacts arising at 7 T from long T2∗ scalp fat components were reduced by frequency shifting the IR pulse such that those frequencies were inverted likewise. For 8 healthy volunteers, the T2∗ relaxation times of white matter were then quantified. In 20 healthy volunteers, the UTE difference and fraction contrast were evaluated. Finally, in 6 patients with multiple sclerosis (MS), the performance of the technique was assessed.A frequency shift of -1.2 ppm of the IR pulse (i.e. towards the fat frequency) provided a good suppression of artifacts. With this, an ultrashort compartment of (68 ± 6) 
%K 7 tesla, relaxometry (Other)
%K Multiple sclerosis (Other)
%K Myelin (Other)
%K Ultrashort echo time (UTE) (Other)
%K White matter (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34906631
%R 10.1016/j.mri.2021.11.016
%U https://inrepo02.dkfz.de/record/178161