TY  - JOUR
AU  - Müller, Max
AU  - Egger, Nico
AU  - Sommer, Stefan
AU  - Wilferth, Tobias
AU  - Meixner, Christian R
AU  - Laun, Frederik Bernd
AU  - Mennecke, Angelika
AU  - Schmidt, Manuel
AU  - Huhn, Konstantin
AU  - Rothhammer, Veit
AU  - Uder, Michael
AU  - Dörfler, Arnd
AU  - Nagel, Armin
TI  - Direct imaging of white matter ultrashort T2∗ components at 7 tesla.
JO  - Magnetic resonance imaging
VL  - 86
SN  - 0730-725X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2021-03166
SP  - 107 - 117
PY  - 2021
N1  - #LA:E020#
AB  - To demonstrate direct imaging of the white matter ultrashort T2∗ components at 7 Tesla using inversion recovery (IR)-enhanced ultrashort echo time (UTE) MRI. To investigate its characteristics, potentials and limitations, and to establish a clinical protocol.The IR UTE technique suppresses long T2∗ signals within white matter by using adiabatic inversion in combination with dual-echo difference imaging. Artifacts arising at 7 T from long T2∗ scalp fat components were reduced by frequency shifting the IR pulse such that those frequencies were inverted likewise. For 8 healthy volunteers, the T2∗ relaxation times of white matter were then quantified. In 20 healthy volunteers, the UTE difference and fraction contrast were evaluated. Finally, in 6 patients with multiple sclerosis (MS), the performance of the technique was assessed.A frequency shift of -1.2 ppm of the IR pulse (i.e. towards the fat frequency) provided a good suppression of artifacts. With this, an ultrashort compartment of (68 ± 6) 
KW  - 7 tesla, relaxometry (Other)
KW  - Multiple sclerosis (Other)
KW  - Myelin (Other)
KW  - Ultrashort echo time (UTE) (Other)
KW  - White matter (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34906631
DO  - DOI:10.1016/j.mri.2021.11.016
UR  - https://inrepo02.dkfz.de/record/178161
ER  -