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| 001 | 178161 | ||
| 005 | 20240229133801.0 | ||
| 024 | 7 | _ | |a 10.1016/j.mri.2021.11.016 |2 doi |
| 024 | 7 | _ | |a pmid:34906631 |2 pmid |
| 024 | 7 | _ | |a 0730-725X |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2021-03166 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Müller, Max |b 0 |
| 245 | _ | _ | |a Direct imaging of white matter ultrashort T2∗ components at 7 tesla. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2021 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1639982847_32759 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:E020# |
| 520 | _ | _ | |a To demonstrate direct imaging of the white matter ultrashort T2∗ components at 7 Tesla using inversion recovery (IR)-enhanced ultrashort echo time (UTE) MRI. To investigate its characteristics, potentials and limitations, and to establish a clinical protocol.The IR UTE technique suppresses long T2∗ signals within white matter by using adiabatic inversion in combination with dual-echo difference imaging. Artifacts arising at 7 T from long T2∗ scalp fat components were reduced by frequency shifting the IR pulse such that those frequencies were inverted likewise. For 8 healthy volunteers, the T2∗ relaxation times of white matter were then quantified. In 20 healthy volunteers, the UTE difference and fraction contrast were evaluated. Finally, in 6 patients with multiple sclerosis (MS), the performance of the technique was assessed.A frequency shift of -1.2 ppm of the IR pulse (i.e. towards the fat frequency) provided a good suppression of artifacts. With this, an ultrashort compartment of (68 ± 6) % with a T2∗ time of (147 ± 58) μs was quantified with a chemical shift of (-3.6 ± 0.5) ppm from water. Within healthy volunteers' white matter, a stable ultrashort T2∗ fraction contrast was calculated. For the MS patients, a significant fraction reduction in the identified lesions as well as in the normal-appearing white matter was observed.The quantification results indicate that the observed ultrashort components arise primarily from myelin tissue. Direct IR UTE imaging of the white matter ultrashort T2∗ components is thus feasible at 7 T with high quantitative inter-subject repeatability and good detection of signal loss in MS. |
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| 650 | _ | 7 | |a 7 tesla, relaxometry |2 Other |
| 650 | _ | 7 | |a Multiple sclerosis |2 Other |
| 650 | _ | 7 | |a Myelin |2 Other |
| 650 | _ | 7 | |a Ultrashort echo time (UTE) |2 Other |
| 650 | _ | 7 | |a White matter |2 Other |
| 700 | 1 | _ | |a Egger, Nico |b 1 |
| 700 | 1 | _ | |a Sommer, Stefan |b 2 |
| 700 | 1 | _ | |a Wilferth, Tobias |b 3 |
| 700 | 1 | _ | |a Meixner, Christian R |b 4 |
| 700 | 1 | _ | |a Laun, Frederik Bernd |b 5 |
| 700 | 1 | _ | |a Mennecke, Angelika |b 6 |
| 700 | 1 | _ | |a Schmidt, Manuel |b 7 |
| 700 | 1 | _ | |a Huhn, Konstantin |b 8 |
| 700 | 1 | _ | |a Rothhammer, Veit |b 9 |
| 700 | 1 | _ | |a Uder, Michael |b 10 |
| 700 | 1 | _ | |a Dörfler, Arnd |b 11 |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 12 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.mri.2021.11.016 |g Vol. 86, p. 107 - 117 |0 PERI:(DE-600)1500646-3 |p 107 - 117 |t Magnetic resonance imaging |v 86 |y 2021 |x 0730-725X |
| 909 | C | O | |o oai:inrepo02.dkfz.de:178161 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 12 |6 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |
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