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000178195 1001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b0$$eFirst author$$udkfz
000178195 245__ $$aA Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era.
000178195 260__ $$aPhiladelphia, Pa.$$c2022
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000178195 500__ $$a#EA:B062# / 2022 Feb;12(2):331-355
000178195 520__ $$aPediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on 'blastomas,' which variably recapitulate the morphologic maturation of organs from which they originate. SIGNIFICANCE: In this review, we briefly summarize the main features and updates of each chapter of the inaugural WHO Classification of Pediatric Tumors, including its rapid transition from a mostly microscopic into a molecularly driven classification systematically taking recent discoveries in pediatric tumor genomics into account.
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000178195 7001_ $$00000-0001-5698-3702$$aReyes-Múgica, Miguel$$b1
000178195 7001_ $$aChan, John K C$$b2
000178195 7001_ $$00000-0003-3976-9231$$aHasle, Henrik$$b3
000178195 7001_ $$00000-0002-6395-4499$$aLazar, Alexander J$$b4
000178195 7001_ $$aRossi, Sabrina$$b5
000178195 7001_ $$00000-0002-4724-0517$$aFerrari, Andrea$$b6
000178195 7001_ $$00000-0002-9027-5686$$aJarzembowski, Jason A$$b7
000178195 7001_ $$00000-0002-2384-9475$$aPritchard-Jones, Kathy$$b8
000178195 7001_ $$00000-0003-1067-3922$$aHill, D Ashley$$b9
000178195 7001_ $$00000-0002-7833-2158$$aJacques, Thomas S$$b10
000178195 7001_ $$00000-0001-5453-5201$$aWesseling, Pieter$$b11
000178195 7001_ $$00000-0002-6584-420X$$aLópez Terrada, Dolores H$$b12
000178195 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b13$$udkfz
000178195 7001_ $$aKratz, Christian P$$b14
000178195 7001_ $$00000-0001-5007-9456$$aCree, Ian A$$b15
000178195 7001_ $$aAlaggio, Rita$$b16
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