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@ARTICLE{Pfister:178195,
      author       = {S. Pfister$^*$ and M. Reyes-Múgica and J. K. C. Chan and
                      H. Hasle and A. J. Lazar and S. Rossi and A. Ferrari and J.
                      A. Jarzembowski and K. Pritchard-Jones and D. A. Hill and T.
                      S. Jacques and P. Wesseling and D. H. López Terrada and A.
                      von Deimling$^*$ and C. P. Kratz and I. A. Cree and R.
                      Alaggio},
      title        = {{A} {S}ummary of the {I}naugural {WHO} {C}lassification of
                      {P}ediatric {T}umors: {T}ransitioning from the {O}ptical
                      into the {M}olecular {E}ra.},
      journal      = {Cancer discovery},
      volume       = {12},
      number       = {2},
      issn         = {2159-8274},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2021-03193},
      pages        = {331-355},
      year         = {2022},
      note         = {#EA:B062# / 2022 Feb;12(2):331-355},
      abstract     = {Pediatric tumors are uncommon, yet are the leading cause of
                      cancer-related death in childhood. Tumor types, molecular
                      characteristics, and pathogenesis are unique, often
                      originating from a single genetic driver event. The specific
                      diagnostic challenges of childhood tumors led to the
                      development of the first World Health Organization (WHO)
                      Classification of Pediatric Tumors. The classification is
                      rooted in a multilayered approach, incorporating morphology,
                      IHC, and molecular characteristics. The volume is organized
                      according to organ sites and provides a single,
                      state-of-the-art compendium of pediatric tumor types. A
                      special emphasis was placed on 'blastomas,' which variably
                      recapitulate the morphologic maturation of organs from which
                      they originate. SIGNIFICANCE: In this review, we briefly
                      summarize the main features and updates of each chapter of
                      the inaugural WHO Classification of Pediatric Tumors,
                      including its rapid transition from a mostly microscopic
                      into a molecularly driven classification systematically
                      taking recent discoveries in pediatric tumor genomics into
                      account.},
      subtyp        = {Review Article},
      cin          = {B062 / HD01 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34921008},
      doi          = {10.1158/2159-8290.CD-21-1094},
      url          = {https://inrepo02.dkfz.de/record/178195},
}