%0 Journal Article
%A Safizadeh, Fatemeh
%A Nguyen, Thi Ngoc Mai
%A Brenner, Hermann
%A Schöttker, Ben
%T Association of Renin-Angiotensin-Aldosterone System inhibition with Covid-19 hospitalization and all-cause mortality in the UK Biobank.
%J British journal of clinical pharmacology
%V 88
%N 6
%@ 0306-5251
%C Oxford
%I Wiley-Blackwell
%M DKFZ-2021-03231
%P 2830-2842
%D 2022
%Z #EA:C070#LA:C070# / 2022 Jun;88(6):2830-2842
%X With growing evidence on the protective effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in coronavirus disease 2019 (Covid-19), we aimed to thoroughly investigate the association between the use of major classes of antihypertensive medications and Covid-19 outcomes in comparison with the use of ACEIs and ARBs.We conducted a population-based study in patients with pre-existing hypertension in the UK Biobank with data from the first two SARS-CoV-2 waves prior population-based vaccination. Multivariable logistic regression analysis was performed adjusting for a wide range of confounders.The use of either beta-blockers (BBs), calcium-channel blockers (CCBs), or diuretics was associated with a higher risk of Covid-19 hospitalization compared to ACEI use (adjusted OR (95
%K Covid-19 (Other)
%K SARS-CoV-2 (Other)
%K angiotensin receptor blockers (Other)
%K angiotensin-converting enzyme inhibitors (Other)
%K hospitalization (Other)
%K hypertension (Other)
%K mortality (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34935181
%R 10.1111/bcp.15192
%U https://inrepo02.dkfz.de/record/178284