TY  - JOUR
AU  - Safizadeh, Fatemeh
AU  - Nguyen, Thi Ngoc Mai
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Association of Renin-Angiotensin-Aldosterone System inhibition with Covid-19 hospitalization and all-cause mortality in the UK Biobank.
JO  - British journal of clinical pharmacology
VL  - 88
IS  - 6
SN  - 0306-5251
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DKFZ-2021-03231
SP  - 2830-2842
PY  - 2022
N1  - #EA:C070#LA:C070# / 2022 Jun;88(6):2830-2842
AB  - With growing evidence on the protective effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in coronavirus disease 2019 (Covid-19), we aimed to thoroughly investigate the association between the use of major classes of antihypertensive medications and Covid-19 outcomes in comparison with the use of ACEIs and ARBs.We conducted a population-based study in patients with pre-existing hypertension in the UK Biobank with data from the first two SARS-CoV-2 waves prior population-based vaccination. Multivariable logistic regression analysis was performed adjusting for a wide range of confounders.The use of either beta-blockers (BBs), calcium-channel blockers (CCBs), or diuretics was associated with a higher risk of Covid-19 hospitalization compared to ACEI use (adjusted OR (95
KW  - Covid-19 (Other)
KW  - SARS-CoV-2 (Other)
KW  - angiotensin receptor blockers (Other)
KW  - angiotensin-converting enzyme inhibitors (Other)
KW  - hospitalization (Other)
KW  - hypertension (Other)
KW  - mortality (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34935181
DO  - DOI:10.1111/bcp.15192
UR  - https://inrepo02.dkfz.de/record/178284
ER  -