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@ARTICLE{Ostrovsky:178305,
      author       = {O. Ostrovsky and K. Beider and Y. Morgulis and N. Bloom and
                      A. Cid-Arregui$^*$ and A. Shimoni and I. Vlodavsky and A.
                      Nagler},
      title        = {{CMV} {S}eropositive {S}tatus {I}ncreases {H}eparanase
                      {SNP}s {R}egulatory {A}ctivity, {R}isk of {A}cute {GVHD} and
                      {Y}ield of {CD}34+ {C}ell {M}obilization.},
      journal      = {Cells},
      volume       = {10},
      number       = {12},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-03252},
      pages        = {3489},
      year         = {2021},
      abstract     = {Heparanase is an endo-β-glucuronidase that is best known
                      for its pro-cancerous effects but is also implicated in the
                      pathogenesis of various viruses. Activation of heparanase is
                      a common strategy to increase viral spread and trigger the
                      subsequent inflammatory cascade. Using a Single Nucleotide
                      Polymorphisms (SNP)-associated approach we identified
                      enhancer and insulator regions that regulate HPSE
                      expression. Although a role for heparanase in viral
                      infection has been noticed, the impact of HPSE functional
                      SNPs has not been determined. We investigated the effect of
                      cytomegalovirus (CMV) serostatus on the involvement of HPSE
                      enhancer and insulator functional SNPs in the risk of acute
                      graft versus host disease (GVHD) and granulocyte-colony
                      stimulating factor related CD34+ mobilization. A significant
                      correlation between the C alleles of insulator rs4364254 and
                      rs4426765 and CMV seropositivity was found in healthy donors
                      and patients with hematological malignancies. The risk of
                      developing acute GVHD after hematopoietic stem cell
                      transplantation was identified only in CMV-seropositive
                      patients. A significant correlation between the enhancer
                      rs4693608 and insulator rs28649799 and CD34+ cell
                      mobilization was demonstrated in the CMV-seropositive
                      donors. It is thus conceivable that latent CMV infection
                      modulates heparanase regulatory regions and enhances the
                      effect of functional SNPs on heparanase function in normal
                      and pathological processes.},
      keywords     = {CMV (Other) / G-CSF-mobilization (Other) / HPSE gene
                      (Other) / SNPs (Other) / acute GVHD (Other) / allogeneic
                      HSCT (Other) / enhancer (Other) / insulator (Other)},
      cin          = {D122},
      ddc          = {570},
      cid          = {I:(DE-He78)D122-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34943994},
      pmc          = {pmc:PMC8700738},
      doi          = {10.3390/cells10123489},
      url          = {https://inrepo02.dkfz.de/record/178305},
}