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000178308 0247_ $$2doi$$a10.3390/diagnostics11122301
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000178308 041__ $$aEnglish
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000178308 1001_ $$00000-0002-0518-5695$$aKamp, Benedikt$$b0
000178308 245__ $$aQuantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI.
000178308 260__ $$aBasel$$bMDPI$$c2021
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000178308 520__ $$aSodium MRI has the potential to depict cartilage health accurately, but synovial fluid can influence the estimation of sodium parameters of cartilage. Therefore, this study aimed to reduce the impact of synovial fluid to render the quantitative compositional analyses of cartilage tissue technically more robust. Two dedicated protocols were applied for determining sodium T1 and T2* relaxation times. For each protocol, data were acquired from 10 healthy volunteers and one patient with patellar cartilage damage. Data recorded with multiple repetition times for T1 measurement and multi-echo data acquired with an additional inversion recovery pulse for T2* measurement were analysed using biexponential models to differentiate longitudinal relaxation components of cartilage (T1,car) and synovial fluid (T1,syn), and short (T2s*) from long (T2l*) transversal relaxation components. Sodium relaxation times and concentration estimates in patellar cartilage were successfully determined: T1,car = 14.5 ± 0.7 ms; T1,syn = 37.9 ± 2.9 ms; c(T1-protocol) = 200 ± 48 mmol/L; T2s* = 0.4 ± 0.1 ms; T2l* = 12.6 ± 0.7 ms; c(T2*-protocol) = 215 ± 44 mmol/L for healthy volunteers. In conclusion, a robust determination of sodium relaxation times is possible at a clinical field strength of 3T to quantify sodium concentrations, which might be a valuable tool to determine cartilage health.
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000178308 650_7 $$2Other$$a23Na
000178308 650_7 $$2Other$$aSodium MRI
000178308 650_7 $$2Other$$abiochemical imaging
000178308 650_7 $$2Other$$acartilage
000178308 650_7 $$2Other$$afluid suppression
000178308 650_7 $$2Other$$ainversion recovery
000178308 650_7 $$2Other$$aknee
000178308 650_7 $$2Other$$aproteoglycan
000178308 650_7 $$2Other$$asodium relaxation times
000178308 7001_ $$00000-0001-5197-6861$$aFrenken, Miriam$$b1
000178308 7001_ $$aHenke, Jan M$$b2
000178308 7001_ $$aAbrar, Daniel B$$b3
000178308 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b4$$udkfz
000178308 7001_ $$aGast, Lena V$$b5
000178308 7001_ $$aOeltzschner, Georg$$b6
000178308 7001_ $$00000-0002-1159-863X$$aWilms, Lena M$$b7
000178308 7001_ $$00000-0002-5267-9962$$aNebelung, Sven$$b8
000178308 7001_ $$aAntoch, Gerald$$b9
000178308 7001_ $$aWittsack, Hans-Jörg$$b10
000178308 7001_ $$aMüller-Lutz, Anja$$b11
000178308 773__ $$0PERI:(DE-600)2662336-5$$a10.3390/diagnostics11122301$$gVol. 11, no. 12, p. 2301 -$$n12$$p2301$$tDiagnostics$$v11$$x2075-4418$$y2021
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