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@ARTICLE{Tavakoli:178310,
      author       = {A. A. Tavakoli$^*$ and C. Dreher$^*$ and A.
                      Mlynarska-Bujny$^*$ and T. A. Kuder$^*$ and R. Gnirs$^*$ and
                      H.-P. Schlemmer$^*$ and S. Bickelhaupt$^*$},
      title        = {{P}ancreatic imaging using diffusivity mapping -
                      {I}nfluence of sequence technique on qualitative and
                      quantitative analysis.},
      journal      = {Clinical imaging},
      volume       = {83},
      issn         = {0899-7071},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2021-03257},
      pages        = {33 - 40},
      year         = {2021},
      note         = {#EA:E010#LA:E250},
      abstract     = {To compare image quality of an optimized diffusion weighted
                      imaging (DWI) sequence with advanced post-processing and
                      motion correction (advanced-EPI) to a standard DWI protocol
                      (standard-EPI) in pancreatic imaging.62 consecutive patients
                      underwent abdominal MRI at 1.5 T were included in this
                      retrospective analysis of data collected as part of an IRB
                      approved study. All patients received a standard-EPI and an
                      advanced-EPI DWI with advanced post-processing and motion
                      correction. Two blinded radiologists evaluated the
                      parameters image quality, detail of parenchyma, sharpness of
                      boundaries and discernibility from adjacent structures on
                      b = 900 s/mm2 images using a Likert-like scale.
                      Segmentation of pancreatic head, body and tail were obtained
                      and apparent diffusion coefficient (ADC) was calculated
                      separately for each region. Apparent tissue-to-background
                      ratio (TBR) was calculated at b = 50 s/mm2 and at
                      b = 900 s/mm2.The advanced-EPI yielded significantly
                      higher scores for pancreatic parameters of image quality,
                      detail level of parenchyma, sharpness of boundaries and
                      discernibility from adjacent structures in comparison to
                      standard-EPI (p < 0.001 for all, kappa = [0.46,0.71])
                      and was preferred in $96\%$ of the cases when directly
                      compared. ADC of the pancreas was $7\%$ lower in
                      advanced-EPI (1.236 ± 0.152 vs.
                      1.146 ± 0.126 μm2/ms, p < 0.001). ADC in the
                      pancreatic tail was significantly lower for both sequences
                      compared to head and body (all p < 0.001). There was
                      comparable TBR for both sequences at b = 50 s/mm2
                      (standard-EPI: 19.0 ± 5.9 vs. advanced-EPI:
                      19.0 ± 6.4, p = 0.96), whereas at b = 900 s/mm2, TBR
                      was $51\%$ higher for advanced-EPI (standard-EPI:
                      7.1 ± 2.5 vs. advanced-EPI: 10.8 ± 5.1,
                      p < 0.001).An advanced DWI sequence might increase image
                      quality for focused imaging of the pancreas and providing
                      improved parenchymal detail levels compared to a standard
                      DWI.},
      keywords     = {Artifacts (Other) / Diffusion magnetic resonance imaging
                      (Other) / Echo-planar imaging (Other) / Magnetic resonance
                      imaging (Other) / Pancreas (Other)},
      cin          = {E010 / E020 / E250},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331 /
                      I:(DE-He78)E250-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34953309},
      doi          = {10.1016/j.clinimag.2021.11.033},
      url          = {https://inrepo02.dkfz.de/record/178310},
}