TY  - JOUR
AU  - Trares, Kira
AU  - Chen, Li-Ju
AU  - Schöttker, Ben
TI  - Association of F2-isoprostane levels with Alzheimer's disease in observational studies: a systematic review and meta-analysis.
JO  - Ageing research reviews
VL  - 74
SN  - 1568-1637
CY  - Oxford [u.a.]
PB  - Elsevier
M1  - DKFZ-2021-03258
SP  - 101552
PY  - 2021
N1  - #EA:C070#LA:C070#
AB  - The association between F2-isoprostanes and Alzheimer's disease (AD) has been controversially discussed in the literature since the 1990s. However, no systematic review has been performed so far.A systematic review of observational studies on the associations of F2-isoprostanes and the specific biomarker 8-iso-prostaglandin F2α with AD were conducted. Random-effects model meta-analyses were performed.29 studies were included in the systematic review, including four longitudinal studies. In an overall meta-analysis of the 25 cross-sectional studies, F2-isoprostane levels were statistically significantly associated with AD (Hedge's g [95
KW  - 8-iso-prostaglandin F(2α) (Other)
KW  - Alzheimer’s Disease (Other)
KW  - F(2)-isoprostanes (Other)
KW  - Observational studies (Other)
KW  - Oxidative stress (Other)
KW  - Systematic review (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34954419
DO  - DOI:10.1016/j.arr.2021.101552
UR  - https://inrepo02.dkfz.de/record/178311
ER  -