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000178322 1001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b0$$eFirst author$$udkfz
000178322 245__ $$aRisk of Late-Onset Depression and Cognitive Decline: Results From Inflammatory Proteome Analyses in a Prospective Population-Based Cohort Study.
000178322 260__ $$a[S.l.]$$bOvid$$c2022
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000178322 500__ $$a#EA:C070#LA:C070# / Volume 30, Issue 6, June 2022, Pages 689-700
000178322 520__ $$aResearch suggests that inflammation is linked to both late-onset depression (LOD) and cognitive decline, and that LOD might have biological underpinnings differentiating it from recurrent depression. Evidence from inflammatory proteome analyses in large prospective cohorts is scarce. The aim of this study was to assess whether and which inflammation-related biomarkers are associated with LOD, recurrent depression, and cognitive decline due to vascular pathology (vascular dementia).Ongoing population-based cohort study of older adults followed for up to 17 years with regard to clinical diagnosis of various age-related diseases (ESTHER study, n = 9,940).Longitudinal cohort started in 2000-2002 in a community setting in Saarland, a southwestern German state.Subgroup of randomly selected participants of the ESTHER study (n = 1,665).Inflammatory biomarkers were measured with the Olink Target 96 in baseline samples.Out of 78 biomarkers interleukin 10 (IL-10) and C-C chemokine ligand 4 (CCL4) were associated with significantly increased risk of LOD after multiple testing correction. Hazard ratios (95-confidence interval) per 1 standard deviation increase were 1.37 (1.15-1.63) for IL-10 and 1.34 (1.13-1.59) for CCL4. None of the inflammatory markers was associated with recurrent depression. The dose-response analysis showed a similar monotonic risk increase for LOD and vascular dementia with increasing IL-10 levels.These results suggest that inflammatory markers are involved in the etiology of LOD, but not of recurrent depression and that LOD and vascular dementia might share common inflammatory etiology with respect to IL-10.
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000178322 650_7 $$2Other$$aLate-onset depression
000178322 650_7 $$2Other$$abiomarker
000178322 650_7 $$2Other$$ainflammation
000178322 650_7 $$2Other$$avascular dementia
000178322 7001_ $$0P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea$$aTrares, Kira$$b1$$udkfz
000178322 7001_ $$aPerneczky, Robert$$b2
000178322 7001_ $$aTato, Maia$$b3
000178322 7001_ $$0P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aStocker, Hannah$$b4$$udkfz
000178322 7001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, Tobias$$b5$$udkfz
000178322 7001_ $$0P:(DE-He78)53e1a2846c69064e27790dbf349ccaec$$aHolleczek, Bernd$$b6$$udkfz
000178322 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b7$$udkfz
000178322 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b8$$eLast author$$udkfz
000178322 773__ $$0PERI:(DE-600)1474415-6$$a10.1016/j.jagp.2021.12.001$$gp. S1064748121005534$$n6$$p689-700$$tAmerican journal of geriatric psychiatry$$v30$$x1064-7481$$y2022
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