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@ARTICLE{Perna:178322,
      author       = {L. Perna$^*$ and K. Trares$^*$ and R. Perneczky and M. Tato
                      and H. Stocker$^*$ and T. Möllers$^*$ and B. Holleczek$^*$
                      and B. Schöttker$^*$ and H. Brenner$^*$},
      title        = {{R}isk of {L}ate-{O}nset {D}epression and {C}ognitive
                      {D}ecline: {R}esults {F}rom {I}nflammatory {P}roteome
                      {A}nalyses in a {P}rospective {P}opulation-{B}ased {C}ohort
                      {S}tudy.},
      journal      = {American journal of geriatric psychiatry},
      volume       = {30},
      number       = {6},
      issn         = {1064-7481},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2021-03269},
      pages        = {689-700},
      year         = {2022},
      note         = {#EA:C070#LA:C070# / Volume 30, Issue 6, June 2022, Pages
                      689-700},
      abstract     = {Research suggests that inflammation is linked to both
                      late-onset depression (LOD) and cognitive decline, and that
                      LOD might have biological underpinnings differentiating it
                      from recurrent depression. Evidence from inflammatory
                      proteome analyses in large prospective cohorts is scarce.
                      The aim of this study was to assess whether and which
                      inflammation-related biomarkers are associated with LOD,
                      recurrent depression, and cognitive decline due to vascular
                      pathology (vascular dementia).Ongoing population-based
                      cohort study of older adults followed for up to 17 years
                      with regard to clinical diagnosis of various age-related
                      diseases (ESTHER study, n = 9,940).Longitudinal cohort
                      started in 2000-2002 in a community setting in Saarland, a
                      southwestern German state.Subgroup of randomly selected
                      participants of the ESTHER study (n = 1,665).Inflammatory
                      biomarkers were measured with the Olink Target 96 in
                      baseline samples.Out of 78 biomarkers interleukin 10 (IL-10)
                      and C-C chemokine ligand 4 (CCL4) were associated with
                      significantly increased risk of LOD after multiple testing
                      correction. Hazard ratios (95-confidence interval) per 1
                      standard deviation increase were 1.37 (1.15-1.63) for IL-10
                      and 1.34 (1.13-1.59) for CCL4. None of the inflammatory
                      markers was associated with recurrent depression. The
                      dose-response analysis showed a similar monotonic risk
                      increase for LOD and vascular dementia with increasing IL-10
                      levels.These results suggest that inflammatory markers are
                      involved in the etiology of LOD, but not of recurrent
                      depression and that LOD and vascular dementia might share
                      common inflammatory etiology with respect to IL-10.},
      keywords     = {Late-onset depression (Other) / biomarker (Other) /
                      inflammation (Other) / vascular dementia (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34961662},
      doi          = {10.1016/j.jagp.2021.12.001},
      url          = {https://inrepo02.dkfz.de/record/178322},
}