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@ARTICLE{Hassan:178372,
      author       = {L. Hassan and L. Efremov and A. Großkopf and N. Kartschmit
                      and D. Medenwald and A. Schott and A. Schmidt-Pokrzywniak
                      and M. E. Lacruz and D. Tiller and F. B. Kraus and K. H.
                      Greiser$^*$ and J. Haerting and K. Werdan and D. Sedding and
                      A. Simm and S. Nuding and A. Kluttig and R. Mikolajczyk},
      title        = {{C}ardiovascular risk factors, living and ageing in
                      {H}alle: the {CARLA} study.},
      journal      = {European journal of epidemiology},
      volume       = {37},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2022-00022},
      pages        = {103–116},
      year         = {2022},
      note         = {37, pages 103–116 (2022)},
      abstract     = {The CARLA study (Cardiovascular Disease, Living and Ageing
                      in Halle) is a longitudinal population-based cohort study of
                      the general population of the city of Halle (Saale),
                      Germany. The primary aim of the cohort was to investigate
                      risk factors for cardiovascular diseases based on
                      comprehensive cardiological phenotyping of study
                      participants and was extended to study factors associated
                      with healthy ageing. In total, 1779 probands (812 women and
                      967 men, aged 45-83 years) were examined at baseline
                      (2002-2005), with a first and second follow-up performed 4
                      and 8 years later. The response proportion at baseline was
                      $64.1\%$ and the reparticipation proportion for the first
                      and second follow-up was $86\%$ and $77\%$ respectively.
                      Sixty-four percent of the study participants were in
                      retirement while $25\%$ were full- or partially-employed and
                      $11\%$ were unemployed at the time of the baseline
                      examination. The currently running third follow-up focuses
                      on the assessment of physical and mental health, with an
                      intensive 4 h examination program, including measurement of
                      cardiovascular, neurocognitive, balance and gait parameters.
                      The data collected in the CARLA Study resulted in answering
                      various research questions in over 80 publications, of which
                      two thirds were pooled analyses with other similar
                      population-based studies. Due to the extensiveness of
                      information on risk factors, subclinical conditions and
                      evident diseases, the biobanking concept for the biosamples,
                      the cohort representativeness of an elderly population, and
                      the high level of quality assurance, the CARLA cohort offers
                      a unique platform for further research on important
                      indicators for healthy ageing.},
      keywords     = {Cardiovascular diseases (Other) / Elderly population
                      (Other) / Healthy ageing (Other) / Population-based cohort
                      study (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34978665},
      doi          = {10.1007/s10654-021-00824-7},
      url          = {https://inrepo02.dkfz.de/record/178372},
}