%0 Journal Article
%A Labadie, Julia D
%A Savas, Sevtap
%A Harrison, Tabitha A
%A Banbury, Barb
%A Huang, Yuhan
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Gallinger, Steven J
%A Giles, Graham G
%A Gunter, Marc J
%A Hoffmeister, Michael
%A Hsu, Li
%A Jenkins, Mark A
%A Lin, Yi
%A Ogino, Shuji
%A Phipps, Amanda I
%A Slattery, Martha L
%A Steinfelder, Robert S
%A Sun, Wei
%A Van Guelpen, Bethany
%A Hua, Xinwei
%A Figuieredo, Jane C
%A Pai, Rish K
%A Nassir, Rami
%A Qi, Lihong
%A Chan, Andrew T
%A Peters, Ulrike
%A Newcomb, Polly A
%T Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.
%J Scientific reports
%V 12
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2022-00051
%P 127
%D 2022
%X Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p = 8.47 × 10-9) and the proximal colon (rs189655236, HR = 2.14, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34996992
%R 10.1038/s41598-021-03945-x
%U https://inrepo02.dkfz.de/record/178424