TY  - JOUR
AU  - Labadie, Julia D
AU  - Savas, Sevtap
AU  - Harrison, Tabitha A
AU  - Banbury, Barb
AU  - Huang, Yuhan
AU  - Buchanan, Daniel D
AU  - Campbell, Peter T
AU  - Gallinger, Steven J
AU  - Giles, Graham G
AU  - Gunter, Marc J
AU  - Hoffmeister, Michael
AU  - Hsu, Li
AU  - Jenkins, Mark A
AU  - Lin, Yi
AU  - Ogino, Shuji
AU  - Phipps, Amanda I
AU  - Slattery, Martha L
AU  - Steinfelder, Robert S
AU  - Sun, Wei
AU  - Van Guelpen, Bethany
AU  - Hua, Xinwei
AU  - Figuieredo, Jane C
AU  - Pai, Rish K
AU  - Nassir, Rami
AU  - Qi, Lihong
AU  - Chan, Andrew T
AU  - Peters, Ulrike
AU  - Newcomb, Polly A
TI  - Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.
JO  - Scientific reports
VL  - 12
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2022-00051
SP  - 127
PY  - 2022
AB  - Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p = 8.47 × 10-9) and the proximal colon (rs189655236, HR = 2.14, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:34996992
DO  - DOI:10.1038/s41598-021-03945-x
UR  - https://inrepo02.dkfz.de/record/178424
ER  -