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@ARTICLE{Labadie:178424,
      author       = {J. D. Labadie and S. Savas and T. A. Harrison and B.
                      Banbury and Y. Huang and D. D. Buchanan and P. T. Campbell
                      and S. J. Gallinger and G. G. Giles and M. J. Gunter and M.
                      Hoffmeister$^*$ and L. Hsu and M. A. Jenkins and Y. Lin and
                      S. Ogino and A. I. Phipps and M. L. Slattery and R. S.
                      Steinfelder and W. Sun and B. Van Guelpen and X. Hua and J.
                      C. Figuieredo and R. K. Pai and R. Nassir and L. Qi and A.
                      T. Chan and U. Peters and P. A. Newcomb},
      title        = {{G}enome-wide association study identifies tumor anatomical
                      site-specific risk variants for colorectal cancer survival.},
      journal      = {Scientific reports},
      volume       = {12},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2022-00051},
      pages        = {127},
      year         = {2022},
      abstract     = {Identification of new genetic markers may improve the
                      prediction of colorectal cancer prognosis. Our objective was
                      to examine genome-wide associations of germline genetic
                      variants with disease-specific survival in an analysis of
                      16,964 cases of colorectal cancer. We analyzed genotype and
                      colorectal cancer-specific survival data from a consortium
                      of 15 studies. Approximately 7.5 million SNPs were examined
                      under the log-additive model using Cox proportional hazards
                      models, adjusting for clinical factors and principal
                      components. Additionally, we ran secondary analyses
                      stratifying by tumor site and disease stage. We used a
                      genome-wide p-value threshold of 5 × 10-8 to assess
                      statistical significance. No variants were statistically
                      significantly associated with disease-specific survival in
                      the full case analysis or in the stage-stratified analyses.
                      Three SNPs were statistically significantly associated with
                      disease-specific survival for cases with tumors located in
                      the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p =
                      8.47 × 10-9) and the proximal colon (rs189655236, HR =
                      2.14, $95\%$ CI 1.65-2.77, p = 9.19 × 10-9 and rs144717887,
                      HR = 2.01, $95\%$ CI 1.57-2.58, p = 3.14 × 10-8), whereas
                      no associations were detected for rectal tumors. Findings
                      from this large genome-wide association study highlight the
                      potential for anatomical-site-stratified genome-wide studies
                      to identify germline genetic risk variants associated with
                      colorectal cancer-specific survival. Larger sample sizes and
                      further replication efforts are needed to more fully
                      interpret these findings.},
      cin          = {C070},
      ddc          = {600},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34996992},
      doi          = {10.1038/s41598-021-03945-x},
      url          = {https://inrepo02.dkfz.de/record/178424},
}