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000178431 0247_ $$2doi$$a10.1016/j.jgo.2021.12.008
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000178431 037__ $$aDKFZ-2022-00058
000178431 041__ $$aEnglish
000178431 082__ $$a610
000178431 1001_ $$aPauleck, Svenja$$b0
000178431 245__ $$aAssociation of circulating leukocyte telomere length with survival in patients with colorectal cancer.
000178431 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2022
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000178431 500__ $$a2022 May;13(4):480-485
000178431 520__ $$aTelomere shortening, as seen with aging, can cause chromosomal instability and promote cancer progression. We investigated the association between circulating telomere length and overall and disease-free survival in a sub-cohort of patients with colorectal cancer.Baseline genomic DNA from blood leukocytes was extracted from N = 92 newly diagnosed stage I-IV patients with colorectal cancer enrolled at the ColoCare Study site in Heidelberg, Germany. Detailed information on clinicodemographic (including age) and lifestyle risk factors, and clinical outcomes (including recurrence and survival) was collected. Telomere length was measured in DNA using multiplex quantitative polymerase chain reaction. Kaplan Meier survival curves were generated comparing shorter to longer telomere lengths with log-rank testing.The mean T/S ratio for study patients was 0.5 (range: 0.3-0.9). Shorter telomeres were associated with older age at baseline. Patients with shorter telomeres experienced a worse overall and disease-free survival, although this association did not reach statistical significance. Kaplan-Meier survival curves for those with circulating telomere length below vs. above the median showed poorer overall (log-rank p = 0.31) and disease-free survival (long-rank p = 0.23).Our results suggest that individuals with shorter telomeres, as seen with aging, may experience a worse overall and disease-free survival after colorectal cancer diagnosis. Larger sample sizes with longer follow-up are needed to further evaluate telomere length as a prognostic biomarker in colorectal cancer progression.
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000178431 650_7 $$2Other$$aColorectal cancer
000178431 650_7 $$2Other$$aDisease-free survival
000178431 650_7 $$2Other$$aLeukocyte telomere length
000178431 650_7 $$2Other$$aOverall survival
000178431 7001_ $$aGigic, Biljana$$b1
000178431 7001_ $$aCawthon, Richard M$$b2
000178431 7001_ $$aOse, Jennifer$$b3
000178431 7001_ $$aPeoples, Anita R$$b4
000178431 7001_ $$aWarby, Christy A$$b5
000178431 7001_ $$aSinnott, Jennifer A$$b6
000178431 7001_ $$aLin, Tengda$$b7
000178431 7001_ $$aBoehm, Juergen$$b8
000178431 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b9$$udkfz
000178431 7001_ $$aLi, Christopher I$$b10
000178431 7001_ $$aShibata, David$$b11
000178431 7001_ $$aSiegel, Erin M$$b12
000178431 7001_ $$aFigueiredo, Jane C$$b13
000178431 7001_ $$aToriola, Adetunji T$$b14
000178431 7001_ $$aSchneider, Martin$$b15
000178431 7001_ $$aUlrich, Alexis B$$b16
000178431 7001_ $$aHoffmeister, Albrecht$$b17
000178431 7001_ $$aUlrich, Cornelia M$$b18
000178431 7001_ $$aHardikar, Sheetal$$b19
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