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@ARTICLE{Pauleck:178431,
      author       = {S. Pauleck and B. Gigic and R. M. Cawthon and J. Ose and A.
                      R. Peoples and C. A. Warby and J. A. Sinnott and T. Lin and
                      J. Boehm and P. Schrotz-King$^*$ and C. I. Li and D. Shibata
                      and E. M. Siegel and J. C. Figueiredo and A. T. Toriola and
                      M. Schneider and A. B. Ulrich and A. Hoffmeister and C. M.
                      Ulrich and S. Hardikar},
      title        = {{A}ssociation of circulating leukocyte telomere length with
                      survival in patients with colorectal cancer.},
      journal      = {Journal of geriatric oncology},
      volume       = {13},
      number       = {4},
      issn         = {1879-4068},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2022-00058},
      pages        = {480-485},
      year         = {2022},
      note         = {2022 May;13(4):480-485},
      abstract     = {Telomere shortening, as seen with aging, can cause
                      chromosomal instability and promote cancer progression. We
                      investigated the association between circulating telomere
                      length and overall and disease-free survival in a sub-cohort
                      of patients with colorectal cancer.Baseline genomic DNA from
                      blood leukocytes was extracted from N = 92 newly diagnosed
                      stage I-IV patients with colorectal cancer enrolled at the
                      ColoCare Study site in Heidelberg, Germany. Detailed
                      information on clinicodemographic (including age) and
                      lifestyle risk factors, and clinical outcomes (including
                      recurrence and survival) was collected. Telomere length was
                      measured in DNA using multiplex quantitative polymerase
                      chain reaction. Kaplan Meier survival curves were generated
                      comparing shorter to longer telomere lengths with log-rank
                      testing.The mean T/S ratio for study patients was 0.5
                      (range: 0.3-0.9). Shorter telomeres were associated with
                      older age at baseline. Patients with shorter telomeres
                      experienced a worse overall and disease-free survival,
                      although this association did not reach statistical
                      significance. Kaplan-Meier survival curves for those with
                      circulating telomere length below vs. above the median
                      showed poorer overall (log-rank p = 0.31) and disease-free
                      survival (long-rank p = 0.23).Our results suggest that
                      individuals with shorter telomeres, as seen with aging, may
                      experience a worse overall and disease-free survival after
                      colorectal cancer diagnosis. Larger sample sizes with longer
                      follow-up are needed to further evaluate telomere length as
                      a prognostic biomarker in colorectal cancer progression.},
      keywords     = {Colorectal cancer (Other) / Disease-free survival (Other) /
                      Leukocyte telomere length (Other) / Overall survival
                      (Other)},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34998722},
      doi          = {10.1016/j.jgo.2021.12.008},
      url          = {https://inrepo02.dkfz.de/record/178431},
}