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000178445 1001_ $$aStalmann, Ursula S A$$b0
000178445 245__ $$aGenetic barcoding systematically comparing genes in del(5q) MDS reveals a central role for CSNK1A1 in clonal expansion.
000178445 260__ $$aWashington, DC$$bAmerican Society of Hematology$$c2022
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000178445 500__ $$a2022 Mar 22;6(6):1780-1796
000178445 520__ $$aHow genetic haploinsufficiency contributes to the clonal dominance of hematopoietic stem cells (HSC) in del(5q) myelodysplastic syndrome (MDS) remains unresolved. Using a genetic barcoding strategy, a systematic comparison was carried out on genes implicated in the pathogenesis of del(5q) MDS in direct competition with each other and wild-type (WT) cells with single clone resolution. Csnk1a1 haploinsufficient HSCs expanded (oligo)clonally and outcompeted all other tested genes and combinations. Csnk1a1-/+ multipotent progenitors showed a pro-proliferative gene signature and HSCs a downregulation of inflammatory signaling/immune response. In validation experiments, Csnk1a1-/+ HSCs outperformed their WT counterparts under a chronic inflammation stimulus, also known to be caused by neighboring genes on chromosome 5. A crucial role for Csnk1a1 haploinsufficiency in the selective advantage of the 5q- HSC is therefore proposed. It is implemented by creation of a unique competitive advantage through increased HSC self-renewal and proliferation capacity, as well as increased fitness under inflammatory stress.
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000178445 7001_ $$00000-0001-8905-6657$$aTicconi, Fabio$$b1
000178445 7001_ $$aSnoeren, Inge A M$$b2
000178445 7001_ $$aLi, Ronghui$$b3
000178445 7001_ $$00000-0001-6138-8916$$aGleitz, Helene$$b4
000178445 7001_ $$aCowley, Glenn$$b5
000178445 7001_ $$aMcConkey, Marie E$$b6
000178445 7001_ $$00000-0003-1650-2710$$aWong, Aaron Benson$$b7
000178445 7001_ $$aSchmitz, Stephani$$b8
000178445 7001_ $$aFuchs, Stijn N R$$b9
000178445 7001_ $$0P:(DE-He78)dbe2fd9578ec0bf59e0e17592b04f22f$$aSood, Shubhankar$$b10
000178445 7001_ $$00000-0003-2530-4329$$aLeimkühler, Nils Bastian$$b11
000178445 7001_ $$aMartinez-Høyer, Sergio$$b12
000178445 7001_ $$aBanjanin, Bella$$b13
000178445 7001_ $$00000-0001-5122-861X$$aRoot, David E$$b14
000178445 7001_ $$00000-0002-9677-3723$$aBrümmendorf, Tim Henrik$$b15
000178445 7001_ $$aPearce, Juliette$$b16
000178445 7001_ $$aSchuppert, Andreas$$b17
000178445 7001_ $$aBindels, Eric$$b18
000178445 7001_ $$0P:(DE-He78)ba3fae49054b6bfaaa289b05ecd936d6$$aEssers, Marieke$$b19$$udkfz
000178445 7001_ $$aHeckl, Dirk$$b20
000178445 7001_ $$00000-0001-9686-9197$$aStiehl, Thomas Peter$$b21
000178445 7001_ $$00000-0003-2890-8697$$aCosta, Ivan G$$b22
000178445 7001_ $$00000-0003-0197-5451$$aEbert, Benjamin L$$b23
000178445 7001_ $$aSchneider, Rebekka K$$b24
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