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@ARTICLE{Zhao:178471,
      author       = {Z. Zhao$^*$ and A. Zhu$^*$ and M. Bhardwaj$^*$ and P.
                      Schrotz-King$^*$ and H. Brenner$^*$},
      title        = {{F}ecal micro{RNA}s, {F}ecal micro{RNA} {P}anels, or
                      {C}ombinations of {F}ecal micro{RNA}s with {F}ecal
                      {H}emoglobin for {E}arly {D}etection of {C}olorectal
                      {C}ancer and {I}ts {P}recursors: {A} {S}ystematic {R}eview.},
      journal      = {Cancers},
      volume       = {14},
      number       = {1},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-00093},
      pages        = {65},
      year         = {2021},
      note         = {#EA:C070#LA:C070#LA:C120#},
      abstract     = {Colorectal cancer (CRC) is the third most common cancer and
                      the second leading cause of cancer mortality globally. Fecal
                      miRNAs have been suggested to be promising biomarkers for
                      CRC early detection. We aimed to conduct a systematic
                      literature review on the diagnostic performance of fecal
                      miRNA markers for CRC and its precursors. PubMed and Web of
                      Science were searched to retrieve relevant articles
                      published up to 7 December 2021. Information on study
                      design, characteristics of study population, pre-analytics
                      (sample collection, processing, and storage), fecal miRNA
                      extraction and quantification technologies, and diagnostic
                      performance (including sensitivity, specificity, and area
                      under the curve (AUC)) were summarized. Twenty studies
                      reporting on 31 individual miRNAs and 16 miRNA panels (with
                      2-9 markers) for CRC diagnosis were identified. Substantial
                      heterogeneity existed regarding stool sample collection,
                      processing, storage, and miRNA extraction and normalization.
                      For two individual miRNAs and one miRNA panel, values ≥
                      $80\%$ were reported for both sensitivity and specificity;
                      however, none of these results were either internally or
                      externally validated. In a study among fecal immunochemical
                      test-positive cases recruited from a true screening setting,
                      better diagnostic performance was identified and internally
                      validated for a combination panel including two miRNAs,
                      fecal hemoglobin level, and patient age and sex, compared
                      with fecal hemoglobin concentration alone. Fecal miRNAs or
                      miRNA panels, possibly in combination with fecal hemoglobin
                      test, may be promising candidates for noninvasive CRC early
                      detection. However, large prospective and well-designed
                      studies in CRC screening cohorts are required to validate
                      promising miRNAs or miRNA panels.},
      subtyp        = {Review Article},
      keywords     = {colorectal cancer (Other) / early detection (Other) / miRNA
                      (Other) / stool (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35008229},
      doi          = {10.3390/cancers14010065},
      url          = {https://inrepo02.dkfz.de/record/178471},
}