TY  - JOUR
AU  - Archambault, Alexi N
AU  - Jeon, Jihyoun
AU  - Lin, Yi
AU  - Thomas, Minta
AU  - Harrison, Tabitha A
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven
AU  - Gruber, Stephen B
AU  - Gunter, Marc J
AU  - Guo, Feng
AU  - Hoffmeister, Michael
AU  - Jenkins, Mark A
AU  - Keku, Temitope O
AU  - Le Marchand, Loïc
AU  - Li, Li
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Pai, Rish
AU  - Parfrey, Patrick S
AU  - Rennert, Gad
AU  - Sakoda, Lori C
AU  - Lee, Jeffrey K
AU  - Slattery, Martha L
AU  - Song, Mingyang
AU  - Ko Win, Aung
AU  - Woods, Michael O
AU  - Murphy, Neil
AU  - Campbell, Peter T
AU  - Su, Yu-Ru
AU  - Lansdorp-Vogelaar, Iris
AU  - Peterse, Elisabeth Fp
AU  - Cao, Yin
AU  - Zeleniuch-Jacquotte, Anne
AU  - Liang, Peter S
AU  - Du, Mengmeng
AU  - Corley, Douglas A
AU  - Hsu, Li
AU  - Peters, Ulrike
AU  - Hayes, Richard B
TI  - Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study.
JO  - Journal of the National Cancer Institute
VL  - 114
IS  - 4
SN  - 0027-8874
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2022-00107
SP  - 528-539
PY  - 2022
N1  -  2022 Apr 11;114(4):528-539
AB  - Incidence of colorectal cancer (CRC) among individuals aged less than 50 years has been increasing. As screening guidelines lower the recommended age of screening initiation, concerns including the burden on screening capacity and costs have been recognized, suggesting that an individualized approach may be warranted. We developed risk prediction models for early-onset CRC that incorporate an environmental risk score (ERS), including 16 lifestyle and environmental factors, and a polygenic risk score (PRS), of 141 variants.Relying on risk score weights for ERS and PRS derived from studies of CRC at all ages, we evaluated risks for early-onset CRC in 3,486 cases and 3,890 controls aged less than 50 years. Relative and absolute risks for early-onset CRC were assessed according to values of the ERS and PRS. The discriminatory performance of these scores was estimated using the covariate-adjusted area under the receiver operating characteristic curve.Increasing values of ERS and PRS were associated with increasing relative risks for early-onset CRC (odds ratio per standard deviation of ERS = 1.14, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:35026030
DO  - DOI:10.1093/jnci/djac003
UR  - https://inrepo02.dkfz.de/record/178510
ER  -