TY  - JOUR
AU  - Lam, Suk Yee
AU  - Mommersteeg, Michiel C
AU  - Yu, Bingting
AU  - Broer, Linda
AU  - Spaander, Manon C W
AU  - Frost, Fabian
AU  - Weiss, Stefan
AU  - Völzke, Henry
AU  - Lerch, Markus M
AU  - Schöttker, Ben
AU  - Zhang, Yan
AU  - Stocker, Hannah
AU  - Brenner, Hermann
AU  - Levy, Daniel
AU  - Hwang, Shih-Jen
AU  - Wood, Alexis C
AU  - Rich, Stephen S
AU  - Rotter, Jerome I
AU  - Taylor, Kent D
AU  - Tracy, Russell P
AU  - Kabagambe, Edmond K
AU  - Leja, Marcis
AU  - Klovins, Janis
AU  - Peculis, Raitis
AU  - Rudzite, Dace
AU  - Nikitina-Zake, Liene
AU  - Skenders, Girts
AU  - Rovite, Vita
AU  - Uitterlinden, André
AU  - Kuipers, Ernst J
AU  - Fuhler, Gwenny M
AU  - Homuth, Georg
AU  - Peppelenbosch, Maikel P
TI  - Toll-like receptor 1 locus re-examined in a genome-wide association study update on anti-Helicobacter pylori IgG titers.
JO  - Gastroenterology
VL  - 162
IS  - 6
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2022-00121
SP  - 1705-1715
PY  - 2022
N1  - 2022 May;162(6):1705-1715
AB  - A genome-wide significant association between anti-Helicobacter pylori (H. pylori) IgG titers and Toll-like receptor (TLR1/6/10) locus on 4p14 was demonstrated for individuals of European ancestry, but not uniformly replicated. We re-investigate this association in an updated genome-wide association study (GWAS) meta-analysis for low gastric cancer incidence populations, address potential causes of cohort heterogeneity and explore functional implications of genetic variation at the TLR1/6/10 locus.The dichotomous GWAS (25
KW  - Polymorphism (Other)
KW  - Single Nucleotide (Other)
KW  - bacteria (Other)
KW  - immunity (Other)
KW  - serology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35031300
DO  - DOI:10.1053/j.gastro.2022.01.011
UR  - https://inrepo02.dkfz.de/record/178524
ER  -