%0 Journal Article
%A Niedermaier, Tobias
%A Balavarca, Yesilda
%A Gies, Anton
%A Weigl, Korbinian
%A Guo, Feng
%A Alwers, Elizabeth
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Variation of positive predictive values of fecal immunochemical tests by polygenic risk score in a large screening cohort.
%J Clinical and translational gastroenterology
%V 13
%N 3
%@ 2155-384X
%C London
%I Nature Publ. Group
%M DKFZ-2022-00139
%P e00458
%D 2022
%Z #EA:C070#LA:C070#LA:C120# / 2022 Jan 19;13(3):e00458
%X Prevalence of colorectal neoplasms varies by polygenic risk scores (PRS). We aimed to assess to what extent PRS might be relevant for defining personalized cutoff values for fecal immunochemical tests (FITs) in colorectal cancer (CRC) screening.Among 5,306 participants of screening colonoscopy who provided a stool sample for a quantitative FIT (Ridascreen Hemoglobin or FOB Gold) prior to colonoscopy a PRS was determined, based on the number of risk alleles in 140 , single nucleotide polymorphism. Subjects were classified into low, medium and high genetic risk for colorectal neoplasms according to PRS tertiles. We calculated positive predictive values (PPVs) and numbers needed to scope (NNS) to detect one advanced neoplasm (AN) by risk group, and cutoff variation needed to achieve comparable PPVs across risk groups in the samples tested with Ridascreen (N=1,271) and FOB Gold (N=4,035) independently, using cutoffs yielding 85
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35060941
%R 10.14309/ctg.0000000000000458
%U https://inrepo02.dkfz.de/record/178590