TY  - JOUR
AU  - Prochazkova, Magdalena
AU  - Budinska, Eva
AU  - Kuzma, Marek
AU  - Pelantova, Helena
AU  - Hradecky, Jaromir
AU  - Heczkova, Marie
AU  - Daskova, Nikola
AU  - Bratova, Miriam
AU  - Modos, Istvan
AU  - Videnska, Petra
AU  - Splichalova, Petra
AU  - Sowah, Solomon A
AU  - Kralova, Maria
AU  - Henikova, Marina
AU  - Selinger, Eliska
AU  - Klima, Krystof
AU  - Chalupsky, Karel
AU  - Sedlacek, Radislav
AU  - Landberg, Rikard
AU  - Kühn, Tilman
AU  - Gojda, Jan
AU  - Cahova, Monika
TI  - Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross-Sectional Multi-Omics Study.
JO  - Frontiers in nutrition
VL  - 8
SN  - 2296-861X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2022-00162
SP  - 783302
PY  - 2022
AB  - Background and Aim: Plant-based diets are associated with potential health benefits, but the contribution of gut microbiota remains to be clarified. We aimed to identify differences in key features of microbiome composition and function with relevance to metabolic health in individuals adhering to a vegan vs. omnivore diet. Methods: This cross-sectional study involved lean, healthy vegans (n = 62) and omnivore (n = 33) subjects. We assessed their glucose and lipid metabolism and employed an integrated multi-omics approach (16S rRNA sequencing, metabolomics profiling) to compare dietary intake, metabolic health, gut microbiome, and fecal, serum, and urine metabolomes. Results: The vegans had more favorable glucose and lipid homeostasis profiles than the omnivores. Long-term reported adherence to a vegan diet affected only 14.8
KW  - metabolic health (Other)
KW  - omics signature (Other)
KW  - protein fermentation (Other)
KW  - short-chain fatty acids (SCFAs) (Other)
KW  - vegan diet (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35071294
C2  - pmc:PMC8777108
DO  - DOI:10.3389/fnut.2021.783302
UR  - https://inrepo02.dkfz.de/record/178613
ER  -