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000178673 0247_ $$2ISSN$$a1435-1293
000178673 0247_ $$2ISSN$$a1436-6207
000178673 0247_ $$2ISSN$$a1436-6215
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000178673 037__ $$aDKFZ-2022-00189
000178673 041__ $$aEnglish
000178673 082__ $$a610
000178673 1001_ $$aCayssials, Valerie$$b0
000178673 245__ $$aInflammatory potential of diet and pancreatic cancer risk in the EPIC study.
000178673 260__ $$aHeidelberg$$bSpringer$$c2022
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000178673 500__ $$a61, pages 2313–2320 (2022)
000178673 520__ $$aThere is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants.After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC.Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02-1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions.To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.
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000178673 650_7 $$2Other$$aDietary patterns
000178673 650_7 $$2Other$$aEpidemiology
000178673 650_7 $$2Other$$aInflammatory potential of diet
000178673 650_7 $$2Other$$aPancreatic cancer
000178673 650_7 $$2Other$$aProspective cohort
000178673 7001_ $$aBuckland, Genevieve$$b1
000178673 7001_ $$aCrous-Bou, Marta$$b2
000178673 7001_ $$aBonet, Catalina$$b3
000178673 7001_ $$aWeiderpass, Elisabete$$b4
000178673 7001_ $$aSkie, Guri$$b5
000178673 7001_ $$aAune, Dagfinn$$b6
000178673 7001_ $$aHeath, Alicia$$b7
000178673 7001_ $$aNøst, Therese Haugdahl$$b8
000178673 7001_ $$aMasala, Giovanna$$b9
000178673 7001_ $$aAgnoli, Claudia$$b10
000178673 7001_ $$aDe Magistris, Maria Santucci$$b11
000178673 7001_ $$aBueno-de-Mesquita, Bas$$b12
000178673 7001_ $$aDerksen, Jeroen$$b13
000178673 7001_ $$aHuybrechts, Inge$$b14
000178673 7001_ $$aFerrari, Pietro$$b15
000178673 7001_ $$aFranklin, Oscar$$b16
000178673 7001_ $$aBodén, Stina$$b17
000178673 7001_ $$aSchulze, Matthias$$b18
000178673 7001_ $$aHuerta, Jose Maria$$b19
000178673 7001_ $$aBarricarte, Aurelio$$b20
000178673 7001_ $$aSacerdote, Carlotta$$b21
000178673 7001_ $$aAmiano, Pilar$$b22
000178673 7001_ $$aTumino, Rosario$$b23
000178673 7001_ $$aMolina-Montes, Esther$$b24
000178673 7001_ $$aTjønneland, Anne$$b25
000178673 7001_ $$aKyrø, Cecilie$$b26
000178673 7001_ $$aSeveri, Gianluca$$b27
000178673 7001_ $$aBoutron-Ruault, Marie-Christine$$b28
000178673 7001_ $$aRebours, Vinciane$$b29
000178673 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b30$$udkfz
000178673 7001_ $$00000-0003-0672-8847$$aAgudo, Antonio$$b31
000178673 7001_ $$aJakszyn, Paula$$b32
000178673 773__ $$0PERI:(DE-600)1463312-7$$a10.1007/s00394-022-02809-y$$p2313–2320$$tEuropean journal of nutrition$$v61$$x0044-264X$$y2022
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