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@ARTICLE{Cayssials:178673,
      author       = {V. Cayssials and G. Buckland and M. Crous-Bou and C. Bonet
                      and E. Weiderpass and G. Skie and D. Aune and A. Heath and
                      T. H. Nøst and G. Masala and C. Agnoli and M. S. De
                      Magistris and B. Bueno-de-Mesquita and J. Derksen and I.
                      Huybrechts and P. Ferrari and O. Franklin and S. Bodén and
                      M. Schulze and J. M. Huerta and A. Barricarte and C.
                      Sacerdote and P. Amiano and R. Tumino and E. Molina-Montes
                      and A. Tjønneland and C. Kyrø and G. Severi and M.-C.
                      Boutron-Ruault and V. Rebours and V. Katzke$^*$ and A. Agudo
                      and P. Jakszyn},
      title        = {{I}nflammatory potential of diet and pancreatic cancer risk
                      in the {EPIC} study.},
      journal      = {European journal of nutrition},
      volume       = {61},
      issn         = {0044-264X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-00189},
      pages        = {2313–2320},
      year         = {2022},
      note         = {61, pages 2313–2320 (2022)},
      abstract     = {There is existing evidence on the potential role of chronic
                      inflammation in the pathogenesis of pancreatic cancer (PC)
                      and on how risk may be modulated by dietary factors.
                      Pro-inflammatory diets are suggested to be associated with
                      increased risk of PC but, so far, evidence remains not
                      conclusive. We examined the association between the dietary
                      inflammatory potential and PC risk within the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      study, which includes 450,112 participants.After a 14-year
                      follow-up, a total of 1239 incident PC cases were included
                      in this study. The inflammatory potential of the diet was
                      estimated using an Inflammatory Score of the Diet (ISD).
                      Hazard ratios (HRs) and $95\%$ confidence intervals (CIs)
                      for the association between the ISD and PC were estimated
                      using multivariable Cox regression models, adjusted for
                      known risk factors for PC.Participants with higher ISDs had
                      a higher risk of developing PCs. In the fully adjusted
                      multivariate model, the risk of PC increased by $11\%$ (HR
                      1.11, $95\%$ CI 1.02-1.22) for 1 point each standard
                      deviation increase in the ISD score. Neither obesity nor any
                      other known risk factor for PC showed statistically
                      significant interactions.To the best of our knowledge, this
                      is the first prospective study reporting a positive
                      relationship between the inflammatory potential of diet and
                      PC. Since early diagnosis and treatment of pancreatic cancer
                      might be challenging, prevention remains the major hope for
                      reducing the burden of this disease.},
      keywords     = {Dietary patterns (Other) / Epidemiology (Other) /
                      Inflammatory potential of diet (Other) / Pancreatic cancer
                      (Other) / Prospective cohort (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35091827},
      doi          = {10.1007/s00394-022-02809-y},
      url          = {https://inrepo02.dkfz.de/record/178673},
}