%0 Journal Article
%A Srour, Bernard
%A Hynes, Lucas Cory
%A Johnson, Theron
%A Kühn, Tilman
%A Katzke, Verena A
%A Kaaks, Rudolf
%T Serum markers of biological ageing provide long-term prediction of life expectancy-a longitudinal analysis in middle-aged and older German adults.
%J Age & ageing
%V 51
%N 2
%@ 0002-0729
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2022-00286
%P afab271
%D 2022
%Z #EA:C020#LA:C020#
%X lifestyle behaviours and chronic co-morbidities are leading risk factors for premature mortality and collectively predict wide variability in individual life expectancy (LE). We investigated whether a pre-selected panel of five serum markers of biological ageing could improve predicting the long-term mortality risk and LE in middle-aged and older women and men.we conducted a case-cohort study (n = 5,789 among which there were 2,571 deaths) within the European Prospective Investigation into Cancer-Heidelberg cohort, a population cohort of middle-aged and older individuals, followed over a median duration of 18 years. Gompertz models were used to compute multi-adjusted associations of growth differentiation factor-15, N-terminal pro-brain natriuretic peptide, glycated haemoglobin A1c, C-reactive protein and cystatin-C with mortality risk. Areas under estimated Gompertz survival curves were used to estimate the LE of individuals using a model with lifestyle-related risk factors only (smoking history, body mass index, waist circumference, alcohol, physical inactivity, diabetes and hypertension), or with lifestyle factors plus the ageing-related markers.a model including only lifestyle-related factors predicted a LE difference of 16.8 [95
%K ageing biomarkers (Other)
%K biological ageing (Other)
%K life expectancy (Other)
%K lifestyle factors (Other)
%K prevention older people (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35150586
%R 10.1093/ageing/afab271
%U https://inrepo02.dkfz.de/record/178822