TY  - JOUR
AU  - Srour, Bernard
AU  - Hynes, Lucas Cory
AU  - Johnson, Theron
AU  - Kühn, Tilman
AU  - Katzke, Verena A
AU  - Kaaks, Rudolf
TI  - Serum markers of biological ageing provide long-term prediction of life expectancy-a longitudinal analysis in middle-aged and older German adults.
JO  - Age & ageing
VL  - 51
IS  - 2
SN  - 0002-0729
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2022-00286
SP  - afab271
PY  - 2022
N1  - #EA:C020#LA:C020#
AB  - lifestyle behaviours and chronic co-morbidities are leading risk factors for premature mortality and collectively predict wide variability in individual life expectancy (LE). We investigated whether a pre-selected panel of five serum markers of biological ageing could improve predicting the long-term mortality risk and LE in middle-aged and older women and men.we conducted a case-cohort study (n = 5,789 among which there were 2,571 deaths) within the European Prospective Investigation into Cancer-Heidelberg cohort, a population cohort of middle-aged and older individuals, followed over a median duration of 18 years. Gompertz models were used to compute multi-adjusted associations of growth differentiation factor-15, N-terminal pro-brain natriuretic peptide, glycated haemoglobin A1c, C-reactive protein and cystatin-C with mortality risk. Areas under estimated Gompertz survival curves were used to estimate the LE of individuals using a model with lifestyle-related risk factors only (smoking history, body mass index, waist circumference, alcohol, physical inactivity, diabetes and hypertension), or with lifestyle factors plus the ageing-related markers.a model including only lifestyle-related factors predicted a LE difference of 16.8 [95
KW  - ageing biomarkers (Other)
KW  - biological ageing (Other)
KW  - life expectancy (Other)
KW  - lifestyle factors (Other)
KW  - prevention older people (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35150586
DO  - DOI:10.1093/ageing/afab271
UR  - https://inrepo02.dkfz.de/record/178822
ER  -