% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{HuynhLe:178825,
      author       = {M.-P. Huynh-Le and R. Karunamuni and C. C. Fan and L. Asona
                      and W. K. Thompson and M. E. Martinez and R. A. Eeles and Z.
                      Kote-Jarai and K. R. Muir and A. Lophatananon and J.
                      Schleutker and N. Pashayan and J. Batra and H. Grönberg and
                      D. E. Neal and B. G. Nordestgaard and C. M. Tangen and R. J.
                      MacInnis and A. Wolk and D. Albanes and C. A. Haiman and R.
                      C. Travis and W. J. Blot and J. L. Stanford and L. A. Mucci
                      and C. M. L. West and S. F. Nielsen and A. S. Kibel and O.
                      Cussenot and S. I. Berndt and S. Koutros and K. D. Sørensen
                      and C. Cybulski and E. M. Grindedal and F. Menegaux and J.
                      Y. Park and S. A. Ingles and C. Maier and R. J. Hamilton and
                      B. S. Rosenstein and Y.-J. Lu and S. Watya and A. Vega and
                      M. Kogevinas and F. Wiklund and K. L. Penney and C. D. Huff
                      and M. R. Teixeira and L. Multigner and R. J. Leach and H.
                      Brenner$^*$ and E. M. John and R. Kaneva and C. J.
                      Logothetis and S. L. Neuhausen and K. De Ruyck and P. Ost
                      and A. Razack and L. F. Newcomb and J. H. Fowke and M.
                      Gamulin and A. Abraham and F. Claessens and J. E. Castelao
                      and P. A. Townsend and D. C. Crawford and G. Petrovics and
                      R. H. N. van Schaik and M.-É. Parent and J. J. Hu and W.
                      Zheng and I. S. S. Committee and I. G. Mills and O. A.
                      Andreassen and A. M. Dale and T. M. Seibert},
      collaboration = {UKGPCS collaborators and APCB and N. P. Investigators and
                      Collaborators and C. P. Investigators and P. S. S. Committee
                      and P. Consortium},
      title        = {{P}rostate cancer risk stratification improvement across
                      multiple ancestries with new polygenic hazard score.},
      journal      = {Prostate cancer and prostatic diseases},
      volume       = {25},
      number       = {4},
      issn         = {1365-7852},
      address      = {Basingstoke},
      publisher    = {Stockton Press},
      reportid     = {DKFZ-2022-00289},
      pages        = {755-761},
      year         = {2022},
      note         = {2022 Apr;25(4):755-761},
      abstract     = {Prostate cancer risk stratification using single-nucleotide
                      polymorphisms (SNPs) demonstrates considerable promise in
                      men of European, Asian, and African genetic ancestries, but
                      there is still need for increased accuracy. We evaluated
                      whether including additional SNPs in a prostate cancer
                      polygenic hazard score (PHS) would improve associations with
                      clinically significant prostate cancer in multi-ancestry
                      datasets.In total, 299 SNPs previously associated with
                      prostate cancer were evaluated for inclusion in a new PHS,
                      using a LASSO-regularized Cox proportional hazards model in
                      a training dataset of 72,181 men from the PRACTICAL
                      Consortium. The PHS model was evaluated in four testing
                      datasets: African ancestry, Asian ancestry, and two of
                      European Ancestry-the Cohort of Swedish Men (COSM) and the
                      ProtecT study. Hazard ratios (HRs) were estimated to compare
                      men with high versus low PHS for association with clinically
                      significant, with any, and with fatal prostate cancer. The
                      impact of genetic risk stratification on the positive
                      predictive value (PPV) of PSA testing for clinically
                      significant prostate cancer was also measured.The final
                      model (PHS290) had 290 SNPs with non-zero coefficients.
                      Comparing, for example, the highest and lowest quintiles of
                      PHS290, the hazard ratios (HRs) for clinically significant
                      prostate cancer were 13.73 $[95\%$ CI: 12.43-15.16] in
                      ProtecT, 7.07 [6.58-7.60] in African ancestry, 10.31
                      [9.58-11.11] in Asian ancestry, and 11.18 [10.34-12.09] in
                      COSM. Similar results were seen for association with any and
                      fatal prostate cancer. Without PHS stratification, the PPV
                      of PSA testing for clinically significant prostate cancer in
                      ProtecT was 0.12 (0.11-0.14). For the top $20\%$ and top
                      $5\%$ of PHS290, the PPV of PSA testing was 0.19 (0.15-0.22)
                      and 0.26 (0.19-0.33), respectively.We demonstrate better
                      genetic risk stratification for clinically significant
                      prostate cancer than prior versions of PHS in multi-ancestry
                      datasets. This is promising for implementing
                      precision-medicine approaches to prostate cancer screening
                      decisions in diverse populations.},
      cin          = {C070 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35152271},
      doi          = {10.1038/s41391-022-00497-7},
      url          = {https://inrepo02.dkfz.de/record/178825},
}