000178881 001__ 178881
000178881 005__ 20240229143558.0
000178881 0247_ $$2doi$$a10.1002/mp.15537
000178881 0247_ $$2pmid$$apmid:35178781
000178881 0247_ $$2ISSN$$a0094-2405
000178881 0247_ $$2ISSN$$a1522-8541
000178881 0247_ $$2ISSN$$a2473-4209
000178881 0247_ $$2altmetric$$aaltmetric:123458272
000178881 037__ $$aDKFZ-2022-00316
000178881 041__ $$aEnglish
000178881 082__ $$a610
000178881 1001_ $$aKalisvaart, Gijsbert M$$b0
000178881 245__ $$aDesign and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging; a feasibility study.
000178881 260__ $$aCollege Park, Md.$$bAAPM$$c2022
000178881 3367_ $$2DRIVER$$aarticle
000178881 3367_ $$2DataCite$$aOutput Types/Journal article
000178881 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1654086997_32
000178881 3367_ $$2BibTeX$$aARTICLE
000178881 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000178881 3367_ $$00$$2EndNote$$aJournal Article
000178881 500__ $$a2022 May;49(5):3093-3106
000178881 520__ $$aAccuracy and precision assessment in radiomic features is important for determination of their potential to characterize cancer lesions. In this regard, simulation of different imaging conditions using specialized phantoms is increasingly being investigated. In this study, the design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomics quantification in hybrid imaging is presented.A modular multimodality imaging phantom was constructed that could simulate different patterns of heterogenous uptake and enhancement patterns in PET, SPECT, CT, and MR imaging. The phantom was designed to be used as an insert in the standard NEMA-NU2 IQ phantom casing. The entire phantom insert is composed out of three segments, each containing three separately fillable compartments. The fillable compartments between segments had different sizes in order to simulate heterogeneous patterns at different spatial scales. The compartments were separately filled with different ratios of 99m Tc-pertechnetate, 18 F-fluorodeoxyglucose, iodine- and gadolinium-based contrast agents for SPECT, PET, CT, and T1 -weigthed MR imaging respectively. Image acquisition was performed using standard oncological protocols on all modalities and repeated five times for repeatability assessment. A total of 93 radiomic features were calculated. Variability was assessed by determining the coefficient of quartile variation (CQV) of the features. Comparison of feature repeatability at different modalities and spatial scales was performed using Kruskal-Wallis-, Mann-Whitney U-, one-way ANOVA- and independent t-tests.Heterogeneous uptake and enhancement could be simulated on all four imaging modalities. Radiomic features in SPECT were significantly less stable than in all other modalities. Features in PET were significantly less stable than in MR and CT. A total of 20 features, particularly in the GLCM and GLRLM class, were found to be relatively stable in all 4 modalities for all 3 spatial scales of heterogeneous patterns (with CQVs <10%).The phantom was suitable for simulating heterogeneous uptake and enhancement patterns in [18 F]FDG-PET, 99m Tc-SPECT, CT, and T1 -weigthed MR images. The results of this work indicate that the phantom might be useful for the further development and optimization of imaging protocols for radiomic quantification in hybrid imaging modalities. This article is protected by copyright. All rights reserved.
000178881 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000178881 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo01.inet.dkfz-heidelberg.de
000178881 650_7 $$2Other$$a3D printing
000178881 650_7 $$2Other$$ahybrid imaging
000178881 650_7 $$2Other$$amultimodality imaging
000178881 650_7 $$2Other$$aphantom studies
000178881 650_7 $$2Other$$aradiomics
000178881 650_7 $$2Other$$arepeatability
000178881 7001_ $$avan Velden, Floris H P$$b1
000178881 7001_ $$aHernández-Girón, Irene$$b2
000178881 7001_ $$aMeijer, Karin M$$b3
000178881 7001_ $$0P:(DE-He78)84edc78dad0b83ad6c0633bd24a0b5b7$$aGhesquiere-Dierickx, Laura M H$$b4$$udkfz
000178881 7001_ $$aBrink, Wyger M$$b5
000178881 7001_ $$aWebb, Andrew$$b6
000178881 7001_ $$ade Geus-Oei, Lioe-Fee$$b7
000178881 7001_ $$aSlump, Cornelis H$$b8
000178881 7001_ $$aKuznetsov, Dimitri V$$b9
000178881 7001_ $$aSchaart, Dennis R$$b10
000178881 7001_ $$aGrootjans, Willem$$b11
000178881 773__ $$0PERI:(DE-600)1466421-5$$a10.1002/mp.15537$$gp. mp.15537$$n5$$p3093-3106$$tMedical physics$$v49$$x0094-2405$$y2022
000178881 909CO $$ooai:inrepo02.dkfz.de:178881$$pVDB
000178881 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)84edc78dad0b83ad6c0633bd24a0b5b7$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000178881 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000178881 9141_ $$y2022
000178881 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2021-02-02$$wger
000178881 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-02
000178881 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-02
000178881 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMED PHYS : 2021$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-12
000178881 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-12
000178881 9201_ $$0I:(DE-He78)E040-20160331$$kE040$$lE040 Med. Physik in der Strahlentherapie$$x0
000178881 980__ $$ajournal
000178881 980__ $$aVDB
000178881 980__ $$aI:(DE-He78)E040-20160331
000178881 980__ $$aUNRESTRICTED