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@ARTICLE{Kalisvaart:178881,
      author       = {G. M. Kalisvaart and F. H. P. van Velden and I.
                      Hernández-Girón and K. M. Meijer and L. M. H.
                      Ghesquiere-Dierickx$^*$ and W. M. Brink and A. Webb and
                      L.-F. de Geus-Oei and C. H. Slump and D. V. Kuznetsov and D.
                      R. Schaart and W. Grootjans},
      title        = {{D}esign and evaluation of a modular multimodality imaging
                      phantom to simulate heterogeneous uptake and enhancement
                      patterns for radiomic quantification in hybrid imaging; a
                      feasibility study.},
      journal      = {Medical physics},
      volume       = {49},
      number       = {5},
      issn         = {0094-2405},
      address      = {College Park, Md.},
      publisher    = {AAPM},
      reportid     = {DKFZ-2022-00316},
      pages        = {3093-3106},
      year         = {2022},
      note         = {2022 May;49(5):3093-3106},
      abstract     = {Accuracy and precision assessment in radiomic features is
                      important for determination of their potential to
                      characterize cancer lesions. In this regard, simulation of
                      different imaging conditions using specialized phantoms is
                      increasingly being investigated. In this study, the design
                      and evaluation of a modular multimodality imaging phantom to
                      simulate heterogeneous uptake and enhancement patterns for
                      radiomics quantification in hybrid imaging is presented.A
                      modular multimodality imaging phantom was constructed that
                      could simulate different patterns of heterogenous uptake and
                      enhancement patterns in PET, SPECT, CT, and MR imaging. The
                      phantom was designed to be used as an insert in the standard
                      NEMA-NU2 IQ phantom casing. The entire phantom insert is
                      composed out of three segments, each containing three
                      separately fillable compartments. The fillable compartments
                      between segments had different sizes in order to simulate
                      heterogeneous patterns at different spatial scales. The
                      compartments were separately filled with different ratios of
                      99m Tc-pertechnetate, 18 F-fluorodeoxyglucose, iodine- and
                      gadolinium-based contrast agents for SPECT, PET, CT, and T1
                      -weigthed MR imaging respectively. Image acquisition was
                      performed using standard oncological protocols on all
                      modalities and repeated five times for repeatability
                      assessment. A total of 93 radiomic features were calculated.
                      Variability was assessed by determining the coefficient of
                      quartile variation (CQV) of the features. Comparison of
                      feature repeatability at different modalities and spatial
                      scales was performed using Kruskal-Wallis-, Mann-Whitney U-,
                      one-way ANOVA- and independent t-tests.Heterogeneous uptake
                      and enhancement could be simulated on all four imaging
                      modalities. Radiomic features in SPECT were significantly
                      less stable than in all other modalities. Features in PET
                      were significantly less stable than in MR and CT. A total of
                      20 features, particularly in the GLCM and GLRLM class, were
                      found to be relatively stable in all 4 modalities for all 3
                      spatial scales of heterogeneous patterns (with CQVs
                      $<10\%).The$ phantom was suitable for simulating
                      heterogeneous uptake and enhancement patterns in [18
                      F]FDG-PET, 99m Tc-SPECT, CT, and T1 -weigthed MR images. The
                      results of this work indicate that the phantom might be
                      useful for the further development and optimization of
                      imaging protocols for radiomic quantification in hybrid
                      imaging modalities. This article is protected by copyright.
                      All rights reserved.},
      keywords     = {3D printing (Other) / hybrid imaging (Other) /
                      multimodality imaging (Other) / phantom studies (Other) /
                      radiomics (Other) / repeatability (Other)},
      cin          = {E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35178781},
      doi          = {10.1002/mp.15537},
      url          = {https://inrepo02.dkfz.de/record/178881},
}