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000178903 041__ $$aEnglish
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000178903 1001_ $$aFresnais, Margaux$$b0
000178903 245__ $$aImportant Requirements for the Selection of Internal Standards during the Development of Desorption/Ionization Assays for Drug Quantification in Biological Matrices-A Practical Example.
000178903 260__ $$aBasel$$bMDPI$$c2022
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000178903 520__ $$aDesorption/ionization mass spectrometry (DI-MS) approaches allow for the rapid quantification of drugs in biological matrices using assays that can be validated according to regulatory guidelines. However, specific adaptations must be applied to create reliable quantification methods, depending on the approach and instrumentation used. In the present article, we demonstrate the importance of the molecular weight, the fragmentation pattern, and the purity of the internal standard for the development of matrix-assisted laser desorption/ionization (MALDI)-ion mobility (IM)-tandem MS and MS/MS methods. We present preliminary results of method development for the quantification of selinexor in microdialysis fluids with a stable isotopically labeled internal standard. In addition, we discuss the selection of internal standards for MALDI-MS assays using different instrumentations.
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000178903 650_7 $$2Other$$abiological matrices
000178903 650_7 $$2Other$$adesorption/ionization
000178903 650_7 $$2Other$$adrug
000178903 650_7 $$2Other$$amass spectrometry
000178903 650_7 $$2Other$$aquantification
000178903 650_7 $$2NLM Chemicals$$aPharmaceutical Preparations
000178903 650_2 $$2MeSH$$aBiological Assay
000178903 650_2 $$2MeSH$$aChromatography, Liquid: methods
000178903 650_2 $$2MeSH$$aMass Spectrometry: methods
000178903 650_2 $$2MeSH$$aMolecular Weight
000178903 650_2 $$2MeSH$$aPharmaceutical Preparations: chemistry
000178903 650_2 $$2MeSH$$aSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: methods
000178903 650_2 $$2MeSH$$aSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: standards
000178903 650_2 $$2MeSH$$aTandem Mass Spectrometry: methods
000178903 7001_ $$aKarabulut, Seda$$b1
000178903 7001_ $$aAbou Zeed, Yasmin$$b2
000178903 7001_ $$00000-0002-7592-1299$$aUngermann, Johannes$$b3
000178903 7001_ $$0P:(DE-He78)2b12a7cfc604eb9816670e995f7af508$$aBenzel, Julia$$b4$$udkfz
000178903 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian W$$b5$$udkfz
000178903 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b6$$udkfz
000178903 7001_ $$00000-0003-0672-6876$$aHaefeli, Walter E$$b7
000178903 7001_ $$00000-0002-2190-1698$$aBurhenne, Jürgen$$b8
000178903 7001_ $$aLonguespée, Rémi$$b9
000178903 773__ $$0PERI:(DE-600)2008644-1$$a10.3390/molecules27030690$$gVol. 27, no. 3, p. 690 -$$n3$$p690$$tMolecules$$v27$$x1420-3049$$y2022
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