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@ARTICLE{Fresnais:178903,
      author       = {M. Fresnais and S. Karabulut and Y. Abou Zeed and J.
                      Ungermann and J. Benzel$^*$ and K. W. Pajtler$^*$ and S. M.
                      Pfister$^*$ and W. E. Haefeli and J. Burhenne and R.
                      Longuespée},
      title        = {{I}mportant {R}equirements for the {S}election of
                      {I}nternal {S}tandards during the {D}evelopment of
                      {D}esorption/{I}onization {A}ssays for {D}rug
                      {Q}uantification in {B}iological {M}atrices-{A} {P}ractical
                      {E}xample.},
      journal      = {Molecules},
      volume       = {27},
      number       = {3},
      issn         = {1420-3049},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-00334},
      pages        = {690},
      year         = {2022},
      abstract     = {Desorption/ionization mass spectrometry (DI-MS) approaches
                      allow for the rapid quantification of drugs in biological
                      matrices using assays that can be validated according to
                      regulatory guidelines. However, specific adaptations must be
                      applied to create reliable quantification methods, depending
                      on the approach and instrumentation used. In the present
                      article, we demonstrate the importance of the molecular
                      weight, the fragmentation pattern, and the purity of the
                      internal standard for the development of matrix-assisted
                      laser desorption/ionization (MALDI)-ion mobility (IM)-tandem
                      MS and MS/MS methods. We present preliminary results of
                      method development for the quantification of selinexor in
                      microdialysis fluids with a stable isotopically labeled
                      internal standard. In addition, we discuss the selection of
                      internal standards for MALDI-MS assays using different
                      instrumentations.},
      keywords     = {Biological Assay / Chromatography, Liquid: methods / Mass
                      Spectrometry: methods / Molecular Weight / Pharmaceutical
                      Preparations: chemistry / Spectrometry, Mass,
                      Matrix-Assisted Laser Desorption-Ionization: methods /
                      Spectrometry, Mass, Matrix-Assisted Laser
                      Desorption-Ionization: standards / Tandem Mass Spectrometry:
                      methods / biological matrices (Other) /
                      desorption/ionization (Other) / drug (Other) / mass
                      spectrometry (Other) / quantification (Other) /
                      Pharmaceutical Preparations (NLM Chemicals)},
      cin          = {B062 / HD01},
      ddc          = {540},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35163955},
      pmc          = {pmc:PMC8838468},
      doi          = {10.3390/molecules27030690},
      url          = {https://inrepo02.dkfz.de/record/178903},
}