%0 Journal Article
%A Hemminki, Kari
%A Försti, Asta
%A Hemminki, Otto
%A Liska, Vaclav
%A Hemminki, Akseli
%T Long-term incidence and survival trends in cancer of the gallbladder and extrahepatic bile ducts in Denmark, Finland, Norway and Sweden with etiological implications related to Thorotrast.
%J International journal of cancer
%V 151
%N 2
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2022-00359
%P 200-208
%D 2022
%Z 2022 Jul 15;151(2):200-208
%X Cancers of the gallbladder and extrahepatic bile ducts (called here 'GBC' because gallbladder cancer is the main component) are rare in Europe, including the Nordic countries. Their incidence has varied for unknown reasons and we hypothesize that Thorotrast, a previously used carcinogenic radiographic contrast medium, has contributed to the incidence trends. We obtained incidence and survival data from the NORDCAN database, which includes cancer registry data from Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE), which are globally the oldest national cancer databases, starting from 1943 in DK, 1953 in FI and NO and 1960 in SE, and extending to 2016. The incidence trend for GBC showed a broad maximum around 1980 in men (close to 3/100,000) and women (4/100,000), except for NO, where this phenomenon was not seen. In 1955, FI and NO incidence rates were equal but FI rates peaked and later declined similar to DK and SE rates. By 2010, the incidence was similar in all Nordic countries, for both men and women, at close to 2.0/100,000. Birth cohort analysis showed strong effects for countries other than NO. Relative 1-year survival increased for men from 20
%K Hepatobiliary carcinoma (Other)
%K gallbladder cancer (Other)
%K incidence trend (Other)
%K relative survival (Other)
%K risk factors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35213036
%R 10.1002/ijc.33980
%U https://inrepo02.dkfz.de/record/178943