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000178948 0247_ $$2doi$$a10.3390/cancers14041071
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000178948 1001_ $$0P:(DE-He78)61de47f47323d5d0b1700e8213e5179f$$aVierthaler, Marlene$$b0$$eFirst author$$udkfz
000178948 245__ $$aADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6.
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000178948 520__ $$aADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motility. In this study, we investigated the role of ADCK2 in melanoma.The effect of ADCK2 on melanoma cell motility was evaluated by a scratch assay and a transwell invasion assay upon siRNA-mediated knockdown or stable overexpression of ADCK2.We found that high levels of intratumoral ADCK2 and MYL6 are associated with a higher survival rate in melanoma patients. Knocking down ADCK2 resulted in enhanced cell migration of melanoma cells. Moreover, ADCK2-knockdown cells adopted a more dedifferentiated phenotype. A gene expression array revealed that the expression of ADCK2 correlated with the expressions of MYL6 and RAB2A. Knocking down MYL6 in ADCK2-overexpressing cells could abrogate the effect of ADCK2 overexpression and thus confirm the functional connection between ADCK2 and MYL6.ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma.
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000178948 650_7 $$2Other$$aADCK2
000178948 650_7 $$2Other$$aMYL6
000178948 650_7 $$2Other$$acancer
000178948 650_7 $$2Other$$amelanoma
000178948 650_7 $$2Other$$amotility
000178948 7001_ $$0P:(DE-He78)f1f0076fc72606659a5df2605acce91b$$aSun, Qian$$b1$$udkfz
000178948 7001_ $$0P:(DE-He78)ada7e359a1f7451130dbc79595227bec$$aWang, Yiman$$b2$$udkfz
000178948 7001_ $$0P:(DE-He78)a65fa5fbdeff5a1bb6ee7de07b820488$$aSteinfass, Tamara$$b3$$udkfz
000178948 7001_ $$0P:(DE-He78)88a268b9173c651561385cddfdf819fa$$aPoelchen, Juliane$$b4$$udkfz
000178948 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b5$$udkfz
000178948 7001_ $$0P:(DE-He78)5f0b1c9863f44d0695555ee3c22b9758$$aNovak, Daniel$$b6$$udkfz
000178948 7001_ $$0P:(DE-He78)38be34240daf8b47325afc7910e77f7b$$aUmansky, Viktor$$b7$$udkfz
000178948 7001_ $$0P:(DE-He78)a229f7724466e7efadf4a1ace1ff8af3$$aUtikal, Jochen$$b8$$eLast author$$udkfz
000178948 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers14041071$$gVol. 14, no. 4, p. 1071 -$$n4$$p1071$$tCancers$$v14$$x2072-6694$$y2022
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