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| 005 | 20240229145529.0 | ||
| 024 | 7 | _ | |a 10.1002/alz.12614 |2 doi |
| 024 | 7 | _ | |a pmid:35234335 |2 pmid |
| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
| 024 | 7 | _ | |a altmetric:123940922 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-00406 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Stocker, Hannah |0 P:(DE-He78)104fae0755c89365b7ae32238b3f1f52 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years. |
| 260 | _ | _ | |a Hoboken, NJ |c 2023 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1674658409_22160 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C070#LA:C070# / 2023 Jan;19(1):25-35 |
| 520 | _ | _ | |a Blood biomarkers for Alzheimer's disease (AD) are the future of AD risk assessment. The aim of this study was to determine the association between plasma-measured phosphorylated tau (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) levels and risk of clinical AD incidence with consideration to the impact of cardiovascular health.Within a community-based cohort, biomarker levels were measured at baseline using single molecule array technology in 768 participants (aged 50-75) followed over 17 years. Associations among biomarkers and AD, vascular dementia, and mixed dementia incidence were assessed.GFAP was associated with clinical AD incidence even more than a decade before diagnosis (9-17 years), while p-tau181 and NfL were associated with more intermediate AD risk (within 9 years). Significant interaction was detected between cardiovascular health and p-tau181/NfL.GFAP may be an early AD biomarker increasing before p-tau181 and NfL and the effect modifying role of cardiovascular health should be considered in biomarker risk stratification. |
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| 650 | _ | 7 | |a Alzheimer's disease |2 Other |
| 650 | _ | 7 | |a blood biomarkers |2 Other |
| 650 | _ | 7 | |a cardiovascular risk |2 Other |
| 650 | _ | 7 | |a risk stratification |2 Other |
| 650 | _ | 7 | |a vascular dementia |2 Other |
| 700 | 1 | _ | |a Beyer, Léon |b 1 |
| 700 | 1 | _ | |a Perna, Laura |b 2 |
| 700 | 1 | _ | |a Rujescu, Dan |b 3 |
| 700 | 1 | _ | |a Holleczek, Bernd |b 4 |
| 700 | 1 | _ | |a Beyreuther, Konrad |b 5 |
| 700 | 1 | _ | |a Stockmann, Julia |b 6 |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 7 |u dkfz |
| 700 | 1 | _ | |a Gerwert, Klaus |b 8 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 9 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/alz.12614 |g p. alz.12614 |0 PERI:(DE-600)2201940-6 |n 1 |p 23 |t Alzheimer's and dementia |v 19 |y 2023 |x 1552-5260 |
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| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2021-01-28 |w ger |
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