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@ARTICLE{Koskinen:179030,
      author       = {A. I. Koskinen and O. Hemminki and A. Försti$^*$ and K.
                      Hemminki},
      title        = {{I}ncidence and survival in oral and pharyngeal cancers in
                      {F}inland and {S}weden through half century.},
      journal      = {BMC cancer},
      volume       = {22},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-00412},
      pages        = {227},
      year         = {2022},
      abstract     = {Cancers of the oral cavity and pharynx encompass a
                      heterogeneous group of cancers for which known risk factors
                      include smoking, alcohol consumption and human papilloma
                      virus (HPV) infection but their influence is site-specific
                      with HPV mainly influencing oropharyngeal cancer. Their
                      incidence and survival rates are not well known over
                      extended periods of time.Data were obtained for Finnish (FI)
                      and Swedish (SE) patients from the Nordcan database recently
                      updated through 2019. Age-adjusted incidence trends (FI from
                      1953, SE from 1960) and relative survival rates for years
                      1970 through 2019 were calculated.We observed a prominent
                      increase in oral and oropharyngeal cancers in FI and SE men
                      and women but the trend for oral cancer was interrupted for
                      SE men in 1985 and possibly also for FI and SE women in
                      2015. The trend changes in male and female oral cancer was
                      confirmed in data for Denmark and Norway. Relative survival
                      for these cancers has improved overall but they differed for
                      one cluster of oral, oropharyngeal and nasopharyngeal
                      cancers with $60-70\%$ 5-year survival in the last period
                      and hypopharyngeal cancer with $25\%$ male survival. In all
                      these cancers, survival for old patients was unfavorable.We
                      hypothesize that reduction in smoking prevalence helped to
                      stop the increase in oral cancer especially in men. As the
                      prevalence of smoking is decreasing, HPV is becoming a
                      dominant risk factor, particularly for the increasing
                      oropharyngeal cancer. Prevention needs to emphasize sexual
                      hygiene and HPV vaccination.},
      keywords     = {Alcohol (Other) / Human papilloma virus (Other) / Oral
                      cancer (Other) / Pharyngeal cancer (Other) / Smoking
                      (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35236321},
      doi          = {10.1186/s12885-022-09337-2},
      url          = {https://inrepo02.dkfz.de/record/179030},
}