TY  - JOUR
AU  - Sowah, Solomon
AU  - Milanese, Alessio
AU  - Schübel, Ruth
AU  - Wirbel, Jakob
AU  - Kartal, Ece
AU  - Johnson, Theron S
AU  - Hirche, Frank
AU  - Grafetstätter, Mirja
AU  - Nonnenmacher, Tobias
AU  - Kirsten, Romy
AU  - López-Nogueroles, Marina
AU  - Lahoz, Agustín
AU  - Schwarz, Kathrin V
AU  - Okun, Jürgen G
AU  - Ulrich, Cornelia M
AU  - Nattenmüller, Johanna
AU  - von Eckardstein, Arnold
AU  - Müller, Daniel
AU  - Stangl, Gabriele I
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
AU  - Zeller, Georg
TI  - Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial.
JO  - Genome medicine
VL  - 14
IS  - 1
SN  - 1756-994X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2022-00491
SP  - 30
PY  - 2022
N1  - #EA:C020#LA:C020#
AB  - The gut microbiota has been suggested to play a significant role in the development of overweight and obesity. However, the effects of calorie restriction on gut microbiota of overweight and obese adults, especially over longer durations, are largely unexplored.Here, we longitudinally analyzed the effects of intermittent calorie restriction (ICR) operationalized as the 5:2 diet versus continuous calorie restriction (CCR) on fecal microbiota of 147 overweight or obese adults in a 50-week parallel-arm randomized controlled trial, the HELENA Trial. The primary outcome of the trial was the differential effects of ICR versus CCR on gene expression in subcutaneous adipose tissue. Changes in the gut microbiome, which are the focus of this publication, were defined as exploratory endpoint of the trial. The trial comprised a 12-week intervention period, a 12-week maintenance period, and a final follow-up period of 26 weeks.Both diets resulted in  5
KW  - Gut microbiome (Other)
KW  - Intermittent calorie restriction (Other)
KW  - Obesity (Other)
KW  - Overweight (Other)
KW  - Weight loss (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35287713
DO  - DOI:10.1186/s13073-022-01030-0
UR  - https://inrepo02.dkfz.de/record/179134
ER  -