% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sowah:179134,
      author       = {S. Sowah$^*$ and A. Milanese and R. Schübel$^*$ and J.
                      Wirbel and E. Kartal and T. S. Johnson$^*$ and F. Hirche and
                      M. Grafetstätter$^*$ and T. Nonnenmacher and R. Kirsten and
                      M. López-Nogueroles and A. Lahoz and K. V. Schwarz and J.
                      G. Okun and C. M. Ulrich and J. Nattenmüller and A. von
                      Eckardstein and D. Müller and G. I. Stangl and R. Kaaks$^*$
                      and T. Kühn$^*$ and G. Zeller},
      title        = {{C}alorie restriction improves metabolic state
                      independently of gut microbiome composition: a randomized
                      dietary intervention trial.},
      journal      = {Genome medicine},
      volume       = {14},
      number       = {1},
      issn         = {1756-994X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2022-00491},
      pages        = {30},
      year         = {2022},
      note         = {#EA:C020#LA:C020#},
      abstract     = {The gut microbiota has been suggested to play a significant
                      role in the development of overweight and obesity. However,
                      the effects of calorie restriction on gut microbiota of
                      overweight and obese adults, especially over longer
                      durations, are largely unexplored.Here, we longitudinally
                      analyzed the effects of intermittent calorie restriction
                      (ICR) operationalized as the 5:2 diet versus continuous
                      calorie restriction (CCR) on fecal microbiota of 147
                      overweight or obese adults in a 50-week parallel-arm
                      randomized controlled trial, the HELENA Trial. The primary
                      outcome of the trial was the differential effects of ICR
                      versus CCR on gene expression in subcutaneous adipose
                      tissue. Changes in the gut microbiome, which are the focus
                      of this publication, were defined as exploratory endpoint of
                      the trial. The trial comprised a 12-week intervention
                      period, a 12-week maintenance period, and a final follow-up
                      period of 26 weeks.Both diets resulted in $~5\%$ weight
                      loss. However, except for Lactobacillales being enriched
                      after ICR, post-intervention microbiome composition did not
                      significantly differ between groups. Overall weight loss was
                      associated with significant metabolic improvements, but not
                      with changes in the gut microbiome. Nonetheless, the
                      abundance of the Dorea genus at baseline was moderately
                      predictive of subsequent weight loss (AUROC of 0.74 for
                      distinguishing the highest versus lowest weight loss
                      quartiles). Despite the lack of consistent intervention
                      effects on microbiome composition, significant study
                      group-independent co-variation between gut bacterial
                      families and metabolic biomarkers, anthropometric measures,
                      and dietary composition was detectable. Our analysis in
                      particular revealed associations between insulin sensitivity
                      (HOMA-IR) and Akkermansiaceae, Christensenellaceae, and
                      Tanerellaceae. It also suggests the possibility of a
                      beneficial modulation of the latter two intestinal taxa by a
                      diet high in vegetables and fiber, and low in processed
                      meat.Overall, our results suggest that the gut microbiome
                      remains stable and highly individual-specific under dietary
                      calorie restriction.The trial, including the present
                      microbiome component, was prospectively registered at
                      ClinicalTrials.gov NCT02449148 on May 20, 2015.},
      keywords     = {Gut microbiome (Other) / Intermittent calorie restriction
                      (Other) / Obesity (Other) / Overweight (Other) / Weight loss
                      (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35287713},
      doi          = {10.1186/s13073-022-01030-0},
      url          = {https://inrepo02.dkfz.de/record/179134},
}