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@ARTICLE{Schwarzbich:179137,
      author       = {M.-A. Schwarzbich and H. Dai$^*$ and L. Kordelas and D. W.
                      Beelen and A. Radujkovic and C. Müller-Tidow and P. Dreger
                      and T. Luft},
      title        = {{P}re-{T}ransplant {S}erum {L}eptin {L}evels and {R}elapse
                      of {A}cute {M}yeloid {L}eukemia after {A}llogeneic
                      {T}ransplantation.},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {4},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2022-00493},
      pages        = {2337},
      year         = {2022},
      abstract     = {Weight loss and metabolic activity influence outcome after
                      allogeneic stem cell transplantation (alloSCT). This study
                      evaluates pre-conditioning Leptin, a peptide hormone
                      involved in metabolism and immune homeostasis, as a
                      prognostic factor for survival, relapse and non-relapse
                      mortality (NRM) following alloSCT. Leptin serum levels prior
                      to conditioning were determined in a cohort of patients
                      transplanted for various hematologic malignancies (n = 524)
                      and correlated retrospectively with clinical outcome.
                      Findings related to patients with acute leukemia (AL) from
                      this sample were validated in an independent cohort. Low
                      pre-conditioning serum Leptin was an independent prognostic
                      marker for increased risk of relapse (but not of NRM and
                      overall mortality) following alloSCT for AL of intermediate
                      and advanced stage (beyond first complete remission).
                      Multivariate analysis revealed a hazard ratio (HR) for
                      relapse of 0.75 per log2 increase (0.59-0.96, p = 0.020).
                      This effect was similar in an independent validation cohort.
                      Pre-conditioning serum Leptin was validated as a prognostic
                      marker for early relapse by fitting the multivariate Cox
                      model to the validation data. Pre-conditioning serum Leptin
                      levels may serve as an independent prognostic marker for
                      relapse following alloSCT in intermediate and advanced stage
                      AL patients. Prospective studies are required to prove
                      whether serum Leptin could be used for guiding nutritional
                      intervention in patients with AL undergoing alloSCT.},
      keywords     = {ALL (Other) / AML (Other) / Adiponectin (Other) / acute
                      lymphoblastic leukemia (Other) / acute myeloid leukemia
                      (Other) / allogeneic stem cell transplantation (Other) /
                      body mass index (Other) / leptin (Other) / relapse (Other) /
                      survival (Other)},
      cin          = {C020},
      ddc          = {540},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35216457},
      pmc          = {pmc:PMC8879842},
      doi          = {10.3390/ijms23042337},
      url          = {https://inrepo02.dkfz.de/record/179137},
}