TY  - JOUR
AU  - Li, Xiangwei
AU  - Jansen, Lina
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Risk of Colorectal Cancer Associated With Lifetime Excess Weight.
JO  - JAMA oncology
VL  - 8
IS  - 5
SN  - 2374-2437
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2022-00495
SP  - 730-737
PY  - 2022
N1  - #EA:C070#LA:C070#LA:C120# 
AB  - Excess weight is associated with increased cancer risk, but the risk may have been underestimated, as previous studies did not consider cumulative lifetime exposure.To assess the association of cumulative lifetime excess weight with risk of colorectal cancer (CRC).In a population-based case-control study conducted since 2003 in Germany, height and self-reported weight documented in 10-year increments starting at age 20 years up to the current age were obtained from 5635 individuals with CRC and 4515 persons serving as controls. Body mass index (BMI), calculated as weight in kilograms divided by height in meters squared, was calculated for each year of age from age 20 years to the current age by linear interpolation. Excess BMI (eBMI) at each year of age was determined as BMI - 25 and summed across ages to obtain the weighted number of years lived with overweight or obesity (WYOs), determined as year × eBMI. The eBMI was set to 0 in case of a BMI below 25. Associations with CRC risk were estimated for BMI at various ages and for WYOs by multiple logistic regression. Data analyses were performed from June 4, 2021, to December 17, 2021.Relative risk of CRC according to lifetime exposure to excess weight compared with relative risks according to BMI at various ages.The mean (SD) age of the patients with CRC (n = 5635) was 68.4 (10.9) years; 3366 were men (59.7
LB  - PUB:(DE-HGF)16
C6  - pmid:35297997
DO  - DOI:10.1001/jamaoncol.2022.0064
UR  - https://inrepo02.dkfz.de/record/179139
ER  -