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@ARTICLE{Li:179139,
      author       = {X. Li$^*$ and L. Jansen$^*$ and J. Chang-Claude$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{R}isk of {C}olorectal {C}ancer {A}ssociated {W}ith
                      {L}ifetime {E}xcess {W}eight.},
      journal      = {JAMA oncology},
      volume       = {8},
      number       = {5},
      issn         = {2374-2437},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2022-00495},
      pages        = {730-737},
      year         = {2022},
      note         = {#EA:C070#LA:C070#LA:C120#},
      abstract     = {Excess weight is associated with increased cancer risk, but
                      the risk may have been underestimated, as previous studies
                      did not consider cumulative lifetime exposure.To assess the
                      association of cumulative lifetime excess weight with risk
                      of colorectal cancer (CRC).In a population-based
                      case-control study conducted since 2003 in Germany, height
                      and self-reported weight documented in 10-year increments
                      starting at age 20 years up to the current age were obtained
                      from 5635 individuals with CRC and 4515 persons serving as
                      controls. Body mass index (BMI), calculated as weight in
                      kilograms divided by height in meters squared, was
                      calculated for each year of age from age 20 years to the
                      current age by linear interpolation. Excess BMI (eBMI) at
                      each year of age was determined as BMI - 25 and summed
                      across ages to obtain the weighted number of years lived
                      with overweight or obesity (WYOs), determined as year ×
                      eBMI. The eBMI was set to 0 in case of a BMI below 25.
                      Associations with CRC risk were estimated for BMI at various
                      ages and for WYOs by multiple logistic regression. Data
                      analyses were performed from June 4, 2021, to December 17,
                      2021.Relative risk of CRC according to lifetime exposure to
                      excess weight compared with relative risks according to BMI
                      at various ages.The mean (SD) age of the patients with CRC
                      (n = 5635) was 68.4 (10.9) years; 3366 were men $(59.7\%);$
                      mean (SD) age of the control participants (n = 4515) was
                      68.5 (10.6) years; 2759 were men $(61.1\%).$ An association
                      was observed between WYOs and CRC risk, with adjusted odds
                      ratios (ORs) increasing from 1.25 $(95\%$ CI, 1.09-1.44) to
                      2.54 $(95\%$ CI, 2.24-2.89) from the first to the fourth
                      quartile of WYOs compared with participants who remained
                      within the normal weight range. Each SD increment in WYOs
                      was associated with an increase of CRC risk by $55\%$
                      (adjusted OR, 1.55; $95\%$ CI, 1.46-1.64). This OR was
                      higher than the OR per SD increase of eBMI at any single
                      point of time, which ranged from 1.04 $(95\%$ CI, 0.93-1.16)
                      to 1.27 $(95\%$ CI 1.16-1.39).The results of this
                      case-control study suggest a greater role of cumulative
                      lifetime excess weight for CRC risk than estimated by
                      traditional analyses based on BMI measures taken at a single
                      point.},
      cin          = {C070 / C020 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35297997},
      doi          = {10.1001/jamaoncol.2022.0064},
      url          = {https://inrepo02.dkfz.de/record/179139},
}