000179149 001__ 179149
000179149 005__ 20240229145535.0
000179149 0247_ $$2doi$$a10.1159/000520821
000179149 0247_ $$2pmid$$apmid:34915510
000179149 0247_ $$2ISSN$$a0378-5858
000179149 0247_ $$2ISSN$$a1011-6524
000179149 0247_ $$2ISSN$$a1420-4096
000179149 0247_ $$2ISSN$$a1423-0143
000179149 0247_ $$2ISSN$$a2571-7146
000179149 0247_ $$2ISSN$$a2571-7154
000179149 0247_ $$2altmetric$$aaltmetric:123597282
000179149 037__ $$aDKFZ-2022-00505
000179149 041__ $$aEnglish
000179149 082__ $$a610
000179149 1001_ $$aFriedrich, Anna-Carolina$$b0
000179149 245__ $$aHemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition.
000179149 260__ $$aBasel [u.a.]$$bKarger$$c2022
000179149 3367_ $$2DRIVER$$aarticle
000179149 3367_ $$2DataCite$$aOutput Types/Journal article
000179149 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1647850060_6127
000179149 3367_ $$2BibTeX$$aARTICLE
000179149 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000179149 3367_ $$00$$2EndNote$$aJournal Article
000179149 520__ $$aThe relationship between Na+ balance and cardiovascular disease (CVD) in hemodialysis (HD) patients is not yet fully understood. We hypothesized that HD patients co-diagnosed with CVD show increased tissue Na+ accumulation compared to HD patients without CVD.In our observational study, 52 HD patients were divided into a group with (23 subjects) or without (29 subjects) a positive history of cardiovascular events. We used 23Na-magnetic resonance imaging (23Na-MRI) at 3.0 Tesla to quantify Na+ content in skin and muscle of both groups directly before and after HD. Additionally, total body fluid distribution was determined by bioimpedance spectroscopy (BIS) and laboratory parameters were assessed.Compared to HD patients without CVD, 23Na-MRI detected an increased Na+ content in skin (21.7 ± 7.3 vs. 30.2 ± 9.8 arbitrary units (a.u.), p < 0.01) and muscle tissue (21.5 ± 3.6 vs. 24.7 ± 6.0 a.u., p < 0.05) in patients with previous CVD events. Simultaneously measured fluid amount by BIS, includingexcess extracellular water (1.8 ± 1.7 vs. 2.2 ± 1.7 L, p = 0.44), was not significantly different between both groups. Tissue Na+ accumulation in HD-CVD patients was paralleled by a higher plasma concentration of the inflammation marker interleukin-6 (5.1, IQR 5.8 vs. 8.5, IQR 7.9 pg/mL, p < 0.05).In our cohort, HD patients with CVD showed higher tissue Na+ content than HD patients without CVD, while no difference in body water distribution could be detected between both groups. Our findings provide evidence that the history of a cardiovascular event is associated with disturbances in tissue Na+ content in HD patients.
000179149 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000179149 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000179149 650_7 $$2Other$$a23Na-magnetic resonance imaging
000179149 650_7 $$2Other$$aCardiovascular disease
000179149 650_7 $$2Other$$aHemodialysis
000179149 650_7 $$2Other$$aTissue Na+
000179149 650_7 $$09NEZ333N27$$2NLM Chemicals$$aSodium
000179149 650_2 $$2MeSH$$aCardiovascular Diseases
000179149 650_2 $$2MeSH$$aHumans
000179149 650_2 $$2MeSH$$aKidney Failure, Chronic: complications
000179149 650_2 $$2MeSH$$aKidney Failure, Chronic: therapy
000179149 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000179149 650_2 $$2MeSH$$aRenal Dialysis
000179149 650_2 $$2MeSH$$aSkin
000179149 650_2 $$2MeSH$$aSodium
000179149 7001_ $$aLinz, Peter$$b1
000179149 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b2$$udkfz
000179149 7001_ $$aRosenhauer, Daniela$$b3
000179149 7001_ $$aHorn, Stephan$$b4
000179149 7001_ $$aSchiffer, Mario$$b5
000179149 7001_ $$aUder, Michael$$b6
000179149 7001_ $$aKopp, Christoph$$b7
000179149 7001_ $$aDahlmann, Anke$$b8
000179149 773__ $$0PERI:(DE-600)1482922-8$$a10.1159/000520821$$gVol. 47, no. 3, p. 185 - 193$$n3$$p185 - 193$$tKidney & blood pressure research$$v47$$x0378-5858$$y2022
000179149 909CO $$ooai:inrepo02.dkfz.de:179149$$pVDB
000179149 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000179149 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000179149 9141_ $$y2022
000179149 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-01-27
000179149 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2022-11-24$$wger
000179149 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bKIDNEY BLOOD PRESS R : 2021$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-01-20T09:19:53Z
000179149 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-01-20T09:19:53Z
000179149 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2022-01-20T09:19:53Z
000179149 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-24
000179149 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-24
000179149 9201_ $$0I:(DE-He78)E020-20160331$$kE020$$lE020 Med. Physik in der Radiologie$$x0
000179149 980__ $$ajournal
000179149 980__ $$aVDB
000179149 980__ $$aI:(DE-He78)E020-20160331
000179149 980__ $$aUNRESTRICTED