%0 Journal Article
%A Dam, Veerle
%A Onland-Moret, N Charlotte
%A Burgess, Stephen
%A Chirlaque, Maria-Dolores
%A Peters, Sanne A E
%A Schuit, Ewoud
%A Tikk, Kaja
%A Weiderpass, Elisabete
%A Oliver-Williams, Clare
%A Wood, Angela M
%A Tjønneland, Anne
%A Dahm, Christina C
%A Overvad, Kim
%A Boutron-Ruault, Marie-Christine
%A Schulze, Matthias B
%A Trichopoulou, Antonia
%A Ferrari, Pietro
%A Masala, Giovanna
%A Krogh, Vittorio
%A Tumino, Rosario
%A Matullo, Giuseppe
%A Panico, Salvatore
%A Boer, Jolanda M A
%A Verschuren, W M Monique
%A Waaseth, Marit
%A Sánchez Pérez, Maria José
%A Amiano, Pilar
%A Imaz, Liher
%A Moreno-Iribas, Conchi
%A Melander, Olle
%A Harlid, Sophia
%A Nordendahl, Maria
%A Wennberg, Patrik
%A Key, Timothy J
%A Riboli, Elio
%A Santiuste, Carmen
%A Kaaks, Rudolf
%A Katzke, Verena
%A Langenberg, Claudia
%A Wareham, Nicholas J
%A Schunkert, Heribert
%A Erdmann, Jeanette
%A Willenborg, Christina
%A Hengstenberg, Christian
%A Kleber, Marcus E
%A Delgado, Graciela
%A März, Winfried
%A Kanoni, Stavroula
%A Dedoussis, George
%A Deloukas, Panos
%A Nikpay, Majid
%A McPherson, Ruth
%A Scholz, Markus
%A Teren, Andrej
%A Butterworth, Adam S
%A van der Schouw, Yvonne T
%T Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization.
%J The journal of clinical endocrinology & metabolism
%V 107
%N 7
%@ 0021-972X
%C Oxford
%I Oxford University Press
%M DKFZ-2022-00512
%P e2952-e2961
%D 2022
%Z 2022 Jun 16;107(7):e2952-e2961
%X Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian Randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men.Two-sample MR, using both cohort data as well as summary statistics, with four methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression.Data from EPIC-CVD and summary statistics from UK Biobank and publicly available GWAS were pooled for the different analyses.CHD, CHD risk factors and ANM.Across different methods of MR no association was found between genetically determined reproductive aging and CHD risk in women (Relative Risk Estimate (RRE)IVW=0.99, 95
%K Mendelian Randomization (Other)
%K Reproductive aging (Other)
%K coronary heart disease (Other)
%K risk factors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35306566
%R 10.1210/clinem/dgac171
%U https://inrepo02.dkfz.de/record/179162